Results 81 to 90 of about 1,403,331 (309)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

They Were the First: Remembering the Creators of Post-War Japanese Fashion

open access: yesЕжегодник Япония
The article is devoted to the recently deceased outstanding Japanese fashion designers, Mori Hanae, Takada Kenzo and Miyake Issey, who can rightfully be called pioneers of post-war Japanese fashion.They not only created a cultural phenomenon based on the
E. L. Katasonova
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The Encoding of Emotions in Ogawa Yōko’s Works: Sensory Narration and Mood Tableaux

open access: yesJapanese Language and Literature
The present article investigates in what way emotions are encoded in the works of Yōko Ogawa and reveals how their potential impact on affect and feelings unfolds. It argues that emotions predominantly occur in their pre-reflective form, i.e.
Elena Giannoulis
doaj   +1 more source

College Quality and Earnings in the Japanese Labor Market [PDF]

open access: yes
The motivations underlying the pursuit of college prestige in Japan presumes a labor market that rewards workers according to the quality of the college that they attended.
Ono, Hiroshi
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

英米児童文学における「死」の表象とスピリチュアリティ ─Charles A. Corr の文献(2004)を中心に─ [PDF]

open access: yes, 2019
  Spirituality has been discussed as an important topic in many other settings as well as in medical ones. It has also been considered to possibly emerge when people are under critical circumstances such as death, dying, and bereavement.
Ubukawa, Emiko, 鵜生川, 恵美子
core  

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