Results 301 to 310 of about 58,844 (318)

Nested PCR for detection of BK virus and JC virus DNA

Clinical and Diagnostic Virology, 1994
A nested polymerase chain reaction (PCR) was developed to detect BK virus (BKV) and JC virus (JCV) DNA sequences. The unique clevage site for BamHI restriction enzyme was located in teh JCV amplimer and cleavage was used to differentiate between BKV and JCV.Twenty-three urine specimens from 17 bone marrow recipients with haemorrhagic cystitis and one ...
Eva Fridell, Anna Lena Hammarin, Maria Brytting, Gordana Bogdanovic, Berit Lönnqvist, Monica Grandien, Paola Cinque, Paola Cinque, Per Ljungman   +8 more
openaire   +4 more sources

No association of JC virus with Alzheimer's disease or astrocytomas

Clinical and Diagnostic Virology, 1995
To investigate if JC virus (JCV) can be involved in the pathogenesis of Alzheimer's disease (AD) and astrocytomas.A nested polymerase chain reaction (PCR) was used for the detection of JCV DNA in autopsy brain material (cerebral white matter) and cerebrospinal fluid (CSF) specimens from patients with AD and age-matched control patients without ...
G. Bogdanovic, I. Nennesmo, A.T. Bergenheim, B. Winblad, A. L. Hammarin, T. Dalianis, Monica Grandien   +6 more
openaire   +3 more sources

[Recent research on the JC virus].

No to shinkei = Brain and nerve, 2007
JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy and belongs to Polyomavirus. In this article we describe our recent research relating to this virus. First, JCV's major capsid protein VP1 possesses a nuclear localization signal (NLS) and has the ability to construct a virus-like particle (VLP).
Hirofumi, Sawa, Tadaki, Suzuki, Yasuko, Orba, Yuji, Sunden, Kazuo, Nagashima   +4 more
openaire   +2 more sources

JC virus leukoencephalopathy complicating Wegener’s granulomatosis

Joint Bone Spine, 2003
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus. It occurs in association with immunodepression due, for instance, to a hematological malignancy, HIV infection, or immunosuppressive therapy for an organ transplant or systemic disease.
Gilles Hayem, Sid Ahmed Rouidi, Christian Pagnoux, E. Palazzo, Fabienne Roux, Olivier Meyer, Dominique Henin   +6 more
openaire   +3 more sources

JC virus as a marker of human migrationto the Americas

Microbes and Infection, 2000
JC virus is a ubiquitous human polyomavirus present in populations worldwide. Seven genotypes differing in DNA sequence by approximately 1-3% characterize three Old World population groups (African, European and Asian) as well as Oceania. It is possible to follow Old World populations into the New World by the JC virus genotypes they carried. The first
Sylvester C. Chima, Caroline F. Ryschkewitsch, Gerald L. Stoner, Mariana Fernandez Cobo, David V. Jobes, Hansjürgen Agostini   +5 more
openaire   +3 more sources

Role of JC virus agnoprotein in virion formation

Microbiology and Immunology, 2012
ABSTRACTJC virus (JCV) belongs to the polyomavirus family of double‐stranded DNA viruses and causes progressive multifocal leukoencephalopathy in humans. JCV encodes early proteins (large T antigen, small T antigen, and T′ antigen) and four late proteins (agnoprotein, and three viral capsid proteins, VP1, VP2, and VP3).
Yuji Sunden, Shingo Semba, Kazuo Nagashima, Yasuko Orba, Tadaki Suzuki, Tadaki Suzuki, Hideki Hasegawa, Hirofumi Sawa, Takashi Kimura, Shintaro Kobayashi   +9 more
openaire   +3 more sources

Regulation of JC virus expression in B lymphocytes

Journal of Virology, 1994
The etiologic agent of progressive multifocal leukoencephalopathy, a subacute demyelinating disease of the central nervous system, is the human polyomavirus JC virus (JCV), which causes a lytic infection of myelin-producing oligodendrocytes. In infected individuals the JCV genome can be detected in brain tissue and B lymphocytes isolated from the blood,
P Rieckmann, U Michel, J H Kehrl
openaire   +3 more sources

Transforming Activities of JC Virus Early Proteins

2007
Polyomaviruses, as their name indicates, are viruses capable of inducing a variety of tumors in vivo. Members of this family, including the human JC and BK viruses (JCV, BKV), and the better characterized mouse polyomavirus and simian virus 40 (SV40), are small DNA viruses that commandeer a cell's molecular machinery to reproduce themselves. Studies of
Shiva K. Tyagarajan, Richard J. Frisque, Catherine A. Hofstetter   +2 more
openaire   +3 more sources

Human anti-JC virus serum reacts with native but not denatured JC virus major capsid protein VP1

Journal of Virological Methods, 1999
The immunoreactivity of human anti-JC virus (JCV) serum against the major capsid protein VP1 of JCV was analyzed by Western blot, dot blot, and hemagglutination inhibition (HAI) assays. JCV-positive human serum reacted with native but not denatured JCV major capsid protein VP1, as demonstrated by dot blot and Western blot.
Wei-Chih Ou, Tsair-Yuh Tzeng, Chih-Kuang Lin, Rong-Tai Tsai, Meilin Wang, Chiung-Yau Fung, Gregory J. Tsay, Deching Chang   +7 more
openaire   +3 more sources

The JC Virus-Like Particle Overlay Assay

2004
JC virus (JCV) belongs to the family of double-stranded DNA polyomaviruses and in humans causes a demyelinating disease of the central nervous system, progressive multifocal leukoencephalopathy (PML). It has been reported that sialic acids play a pivotal role in hemagglutination of red blood cells and entry into host cells of JCV and that JCV can enter
Rika Komagome, Hirofumi Sawa
openaire   +3 more sources