Results 311 to 320 of about 2,027,813 (387)
Real‐time fluorometric isothermal assays for detection of Streptococcus equi subspecies equi and Streptococcus equi subspecies zooepidemicus in horses: Validation, comparison and evaluation of their clinical application
Australian Veterinary Journal, EarlyView.Infectious diseases significantly impact equine health and welfare, causing illness and death, and loss of productivity globally. One such disease is ‘strangles’, a highly contagious upper respiratory condition in horses caused by Streptococcus equi subspecies equi (SEE).M Jelocnik, C Hall, S Dennis, K Mitchell, A Blishen, N Mashkour, SI Anstey, C Jenkins, K Jeffers, C El‐Hage, D McMillan, J Gilkerson +11 morewiley +1 more sourceTau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy
Brain Pathology, EarlyView.The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd +7 morewiley +1 more sourceJC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis
Annals of Neurology, 2014 S. Chalkias, Xin Dang, E. Bord, Marion C. Stein, R. Kinkel, J. Sloane, M. Donnelly, C. Ionete, M. Houtchens, G. Buckle, Stephanie Batson, I. Koralnik +11 moresemanticscholar +1 more sourceVulnerability of marine megafauna to global at‐sea anthropogenic threats
Conservation Biology, EarlyView.Abstract
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened ...Michelle VanCompernolle, Juliet Morris, Hannah J. Calich, Jorge P. Rodríguez, Sarah A. Marley, Jessica R. Pearce, Briana Abrahms, Katya Abrantes, André S. Afonso, Alex Aguilar, Andrews Agyekumhene, Tomonari Akamatsu, Susanne Åkesson, Nyimale G. Alawa, Joanna Alfaro‐Shigueto, R. C. Anderson, Tycho Anker‐Nilssen, Javier A. Arata, Gonzalo Araujo, Martin C. Arostegui, Haritz Arrizabalaga, Lucy M. Arrowsmith, Marie Auger‐Méthé, Isabel C. Avila, Fred Bailleul, Joanna Barker, Dawn R. Barlow, Adam Barnett, Hector Barrios‐Garrido, Alastair M. M. Baylis, Giovanni Bearzi, Lars Bejder, Eduardo J. Belda, Scott R. Benson, Michael L. Berumen, Sophie Bestley, Natalia P. A. Bezerra, Antonin V. Blaison, Lars Boehme, Steven J. Bograd, Bolaji Dunsin Abimbola, Mark E. Bond, Asunción Borrell, Phil J. Bouchet, Peter Boveng, Gill Braulik, Camrin D. Braun, Stephanie Brodie, Leandro Bugoni, Carlos Bustamante, Steven E. Campana, Susana Cárdenas‐Alayza, Ruth H. Carmichael, Gemma Carroll, Matt I. D. Carter, Filipe R. Ceia, Salvatore Cerchio, Luciana C. Ferreira, Philippine Chambault, Taylor K. Chapple, Patricia Charvet, Elpis J. Chavez, Damien Chevallier, Andre Chiaradia, B. Louise Chilvers, Megan A. Cimino, Bethany L. Clark, C. R. Clarke, Thomas A. Clay, Carl S. Cloyed, Jesse E. M. Cochran, Tim Collins, Enric Cortes, Eduardo Cuevas, David J. Curnick, Peter Dann, P. J. Nico de Bruyn, Asha de Vos, Solène Derville, Maria P. Dias, Bruno Diaz‐Lopez, Kara L. Dodge, Alistair D. M. Dove, Thomas K. Doyle, J. Marcus Drymon, Christine L. Dudgeon, Peter H. Dutton, Ursula Ellenberg, Simon H. Elwen, Louise Emmerson, Edem A. Eniang, Mario Espinoza, Nicole Esteban, Evert Mul, Brian S. Fadely, Annette L. Fayet, Chris Feare, Steven H. Ferguson, Laura Joan Feyrer, Brittany Finucci, Katie R. N. Florko, Jorge Fontes, C. M. Fortuna, Sabrina Fossette, Leila Fouda, Esteban Frere, Mariana M. P. B. Fuentes, Austin J. Gallagher, Pablo Garcia Borboroglu, Claire Garrigue, Pauline Gauffier, Enrico Gennari, Tilen Genov, Elitza S. Germanov, Joan Giménez, Matthew H. Godfrey, Brendan J. Godley, Simon D. Goldsworthy, Matthew Gollock, Victoria González Carman, Natasha J. Gownaris, W. James Grecian, Hector M. Guzman, Mark Hamann, Neil Hammerschlag, Erpur S. Hansen, Mike P. Harris, Gordon Hastie, Danielle E. Haulsee, Elliott L. Hazen, Mads Peter Heide‐Jørgensen, Elizabeth E. Hieb, Jeff W. Higdon, Mark A. Hindell, Jefferson T. Hinke, Xavier Hoenner, G. J. Greg Hofmeyr, Bonnie J. Holmes, Erich Hoyt, Luis A. Huckstadt, Nigel E. Hussey, Charlie Huveneers, Lyn G. Irvine, Rima W. Jabado, David M. P. Jacoby, Audrey Jaeger, Patrick M. Jagielski, Mark Jessopp, Oliver J. D. Jewell, David Jiménez Alvarado, Lance K. B. Jordan, Salvador J. Jorgensen, Benjamin Kahn, Alexandros A. Karamanlidis, Akiko Kato, Lucy W. Keith‐Diagne, M. S. Kiani, Jeremy J. Kiszka, Alison A. Kock, R. Keller Kopf, Carey Kuhn, Peter M. Kyne, Kristin L. Laidre, Fernanda O. Lana, Michelle E. Lander, Matthieu Le Corre, Olivia A. Lee, Ruth H. Leeney, Alexis L. Levengood, J. Jacob Levenson, Marcela Libertelli, Kwang‐Ming Liu, Milagros Lopez Mendilaharsu, Alexandra Loveridge, Christopher G. Lowe, Heather J. Lynch, Bruno C. L. Macena, Alice I. Mackay, Jeffry Madrigal‐Mesén, Mark L. Mallory, Jeffrey C. Mangel, Katherine L. Mansfield, David March, Marianne Marcoux, Helene Marsh, A. D. Marshall, Thomas Mattern, Sara M. Maxwell, Rebecca L. McGuire, Lachlan McLeay, Clive R. McMahon, Séverine Methion, Eva K. M. Meyers, Candice Michelot, Cara Masere, Gianna Minton, Benjamin Morales‐Vela, Gonzalo Mucientes, Hilario Murua, M. A. C. Nicoll, Yuri Niella, Giuseppe Notarbartolo di Sciara, Steffen Oppel, Florian Orgeret, Julie N. Oswald, Ellie Owen, Nathan Pacoureau, Vitor H. Paiva, Daniel M. Palacios, Simone Panigada, Yannis P. Papastamatiou, Guido J. Parra, Sylvia K. Parsons, Donna L. Patterson‐Fraser, S. Hoyt Peckham, Stephen D. Petersen, Lorien Pichegru, Simon J. Pierce, Tânia Pipa, Enrico Pirotta, Pierre Pistorius, Riley A. Pollom, Rui Prieto, Laura Prosdocimi, Klemens Pütz, Nuno Queiroz, John L. Quinn, Jaime A. Ramos, Holly C. Raudino, Angela Recalde‐Salas, ALan F. Rees, Richard D. Reina, Ryan R. Reisinger, Samantha D. Reynolds, Anthony James Richardson, Nicholas G. Riddoch, Federico G. Riet‐Sapriza, James R. Robbins, David P. Robinson, Airam Rodríguez, Tracey L. Rogers, Christoph A. Rohner, Daniela Rojas‐Cañizales, Kevin Ruhomaun, Chandra Salgado Kent, Katsufumi Sato, Kylie L. Scales, Meike Scheidat, Gail Schofield, Fabrizio Serena, Edy Setyawan, Scott A. Shaffer, Brendan D. Shea, Laura Shearer, Marcus Sheaves, Richard B. Sherley, George L. Shillinger, Takahiro Shimada, Mónica A. Silva, Gregory Skomal, Reyd A. Smith, Amy F. Smoothey, Alen Soldo, Emily J. Southall, Antje Steinfurth, D. Bruce Stewart, Joshua D. Stewart, Akinori Takahashi, Vikash Tatayah, Sam Thalmann, Jean‐Baptiste Thiebot, Jesús Tomás, Leigh G. Torres, P. N. Trathan, Fritz Trillmich, Kazuoki Ueda, Frederic Vandeperre, Ralph Eric Thijl Vanstreels, Marisa Vedor, Stella Villegas‐Amtmann, Lauren J. Waller, Matt Waller, Sarah Wanless, Kelly Waples, Cortney A. Watt, Mia Wege, Caroline R. Weir, Randall S. Wells, Paul J. Wensveen, Timothy D. White, Scott D. Whiting, Øystein Wiig, Natalie E. Wildermann, David N. Wiley, Jessica Lauren Williams, Rosie S. Williams, Kenady Wilson, Matthew J. Witt, Freya C. Womersley, David J. Yurkowski, Jie Zhang, Daniel P. Costa, Carlos M. Duarte, Mark G. Meekan, Rob Harcourt, David W. Sims, Graeme C. Hays, Charitha Pattiaratchi, Víctor M. Eguíluz, Ana M. M. Sequeira +309 morewiley +1 more sourceAgeing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice
Cell Proliferation, EarlyView.During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan +7 morewiley +1 more sourceOSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension
Cell Proliferation, EarlyView.This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu +12 morewiley +1 more source
