Results 161 to 170 of about 126,105 (358)

Atividade da amilase no intestino delgado de coelhos alimentados com dietas contendo diferentes níveis de amido antes e após desmame = Amylase activity in the small intestine of rabbits fed with diets containing starch levels before and after weaning

open access: yesActa Scientiarum: Animal Sciences, 2006
Para avaliar a atividade amilásica em coelhos após a desmama, foram utilizados 200 animais da Raça Nova Zelândia Branco, submetidos a diferentes padrões de alimentação desde a fase de lactação. Quarenta deles foram abatidos aos 35 dias de idade e 80, aos
Haroldo Garcia de Faria   +5 more
doaj  

Exploring the Role of TAS2Rs in Obesity: Insights From Human and Rat Models

open access: yesObesity, EarlyView.
ABSTRACT Objective Obesity is a chronic disease with various causes and diverse treatments, including dietary restriction and bariatric surgery. Bitter taste receptors (TAS2Rs), found in the oral cavity and gastrointestinal tract (GIT), are implicated in digestive and metabolic regulation, but their role in obesity remains unclear.
Maria Descamps‐Solà   +11 more
wiley   +1 more source

Application of Physiologically‐Based Pharmacokinetic Modeling to Support Drug Labeling: Prediction of CYP3A4‐Mediated Pirtobrutinib‐Drug Interactions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pirtobrutinib is a reversible Bruton tyrosine kinase (BTK) inhibitor. In vitro, pirtobrutinib is metabolized by cytochrome P450 (CYP) 3A4 and uridine 5′‐diphosphoglucuronosyl transferases (UGTs) and causes reversible and time‐dependent inhibition and induction of CYP3A4.
Dan‐Dan Tian   +3 more
wiley   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

open access: yesSmall Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai   +9 more
wiley   +1 more source

Surgeon\u27s perspective on short bowel syndrome: Where are we? [PDF]

open access: yes, 2018
Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required.
Lauro, Augusto, Marino, Ignazio R.
core   +1 more source

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

open access: yesSmall Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz   +5 more
wiley   +1 more source

Proteolytic and peptidase activities of the jejunum and ileum of the rat during postnatal development [PDF]

open access: green, 1966
R. Noack   +5 more
openalex   +1 more source

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