Results 311 to 320 of about 160,447 (386)

Gut‐derived Lactobacillus from exceptional responders mitigates chemoradiotherapy‐induced intestinal injury through methionine‐driven epigenetic modulation

open access: yesiMeta, Volume 4, Issue 3, June 2025.
Using metagenomic sequencing and bioinformatics analysis of fecal samples from rectal cancer patients and corresponding mouse models, our study identifies a strong association between Lactobacillus abundance and acute chemoradiotherapy‐induced intestinal injury (ACRIII). Elevated Lactobacillus levels before treatment were consistently linked to reduced
Lu Yu   +16 more
wiley   +1 more source

Antagonism of 5‐HT7 Receptors as a Promising Target for Gastric Cancer via Apoptotic Pathway

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
Antagonism of 5‐HT7 receptors as an approach for combating gastric cancer through the apoptotic pathway is targeted. The present study aims to unearth potential avenues for advanced therapeutic strategies in the battle against this devastating disease by exploring the intricate interactions between 5‐HT7 receptors and gastric cancer, as well as ...
Irfan Cinar   +6 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling and Simulation to Support a Change in the FDA‐Labeled Dosing Frequency of RHB‐105 Low‐Dose Rifabutin Triple Therapy for Helicobacter pylori Eradication

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 6, Page 779-786, June 2025.
Abstract Patient adherence is vital for Helicobacter pylori eradication. Simplifying therapy dosing schedules may promote patient adherence, enhance treatment success rates, and help mitigate the development of antibiotic resistance. We aimed to assess plasma and intragastric rifabutin, amoxicillin, and omeprazole concentrations comparing two dosing ...
Nimish Vakil   +6 more
wiley   +1 more source

Abstracts

open access: yesMolecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients

open access: yesJGH Open, Volume 9, Issue 6, June 2025.
ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy but are associated with immune‐mediated adverse events (imAEs), including gastrointestinal toxicities. Among these, enteritis is a less common but clinically significant complication.
Masayuki Orikasa   +11 more
wiley   +1 more source

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