Results 31 to 40 of about 277,715 (241)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Sources of UHECRs in view of the TUS and JEM-EUSO experiments

, 2012
The origin of ultra-high-energy cosmic rays (UHECRs) is one of the most intriguing problems of modern cosmic ray physics. We briefly review the main astrophysical models of their origin and the forthcoming orbital experiments TUS and JEM-EUSO, and ...
Abbasi R, Abraham J, B A Khrenov, Benson R, Blasi P, Cazon L, Dar A, Ebisuzaki T, Fang K, G V Kulikov, Hümmer S, Kegel W H, Kotera K, M Yu Zotov, Milgrom M, Mészáros P, N N Kalmykov, Panasyuk M, Ptitsyna K, Rubtsov G I, Sigl G, Vannoni G   +21 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

INTEGRAL high energy monitoring of the X-ray burster KS 1741-293

, 2007
KS 1741-293, discovered in 1989 by the X-ray camera TTM in the Kvant module of the Mir space station and identified as an X-ray burster, has not been detected in the hard X band until the advent of the INTEGRAL observatory.
A. Bazzano, A. Tarana, Barett, Bazzano, Bird, Cherepashchuk, Courvoisier, Di Salvo, G. De Cesare, G. Stratta, Harmon, In't Zand, In't Zand, Lewin, Lewin, Liu, Lund, M. Del Santo, Maraschi, Martí, Mas-Hesse, P. Ubertini, Revnivstev, S. Martínez Núñez, Sakano, Sidoli, Swank, Titarchuk, Ubertini, Vedrenne, White, Winkler, Woosley   +32 more
core   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

X-RAY OBSERVATIONS OF SN 1006 WITH INTEGRAL [PDF]

, 2007
We have used 1000 ksec of on-source, and 500 ksec of 10 degrees off-source INTEGRAL data of SN 1006 to characterize the synchrotron emission, and attempt to detect non-thermal bremsstrahlung, using the combination of IBIS and JEM-X spatial and spectral ...
Boggs, Steven E., Chenevez, Jerome, Kalemci, Emrah, Lund, Niels, Renaud, Matthieu, Reynolds, Stephen   +5 more
core  

Physics Goals and Status of JEM-EUSO and its Test Experiments

, 2015
The JEM-EUSO mission aims to explore the origin of the extreme energy cosmic rays (EECRs) through the observation of air-shower fluorescence light from space.
Collaboration, JEM-EUSO, Haungs, Andreas
core   +1 more source

INTEGRAL detection of hard X-rays from NGC 6334: Nonthermal emission from colliding winds or an AGN? [PDF]

, 2005
We report the detection of hard X-ray emission from the field of the star-forming region NGC 6334 with the the International Gamma-Ray Astrophysics Laboratory INTEGRAL.
Bloemen, H., Bykov, A. M., Courvoisier, T. J. -L., Gustov, M. Yu., Hermsen, W., Krassilchtchikov, A. M., Lebrun, F., Leyder, J. -C., Lozinskaya, T. A., McBreen, B., Rauw, G., Renaud, M., Swings, J. -P., Terrier, R., Uvarov, Yu. A.   +14 more
core   +5 more sources

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +15 more
wiley   +1 more source