Results 91 to 100 of about 15,882 (267)

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Acoustic‐driven surface cleaning with millimeter‐sized bubbles at translational resonance

Droplet, EarlyView.
Time‐lapse visualization comparing bubble trajectories. The top panel (0 Hz) shows a bubble's linear path under no acoustic forcing, while the bottom panel (50 Hz) demonstrates the oscillatory motion induced by acoustic waves at a resonance mode. This mechanism holds promising potential for applications such as surface cleaning.
Yan Jun Lin, Zhengyang Liu, Sunghwan Jung   +2 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Digital Rights Activism in Multilevel Governance

European Policy Analysis, EarlyView.
ABSTRACT Multilevel governance (MLG) without a clear hierarchical structure can create power imbalances among various actors, particularly in settings with overlapping jurisdictions and policy areas. This dynamic is especially pronounced in Internet governance, which faces a complex interplay of domestic laws, state interdependence, and heightened ...
Alison Harcourt
wiley   +1 more source

Biomechanical mechanisms of anterior cruciate ligament injury in the jerk dip phase of clean and jerk: A case study of an injury event captured on-site

Heliyon
Background: Weightlifting exposes athletes to significant loads, potentially placing the knee joint in an abnormal mechanical environment and leading to anterior cruciate ligament (ACL) injuries.
Binyong Ye, Gongju Liu, Zhanyang He, Jun Xu, Huiju Pan, Houwei Zhu   +5 more
doaj   +1 more source

Ictal semiology in fronto‐opercular epilepsy: A systematic review

Epileptic Disorders, EarlyView.
Abstract A systematic review of the ictal semiology of fronto‐opercular seizures in focal epilepsy was carried out to assess possible anatomical‐clinical correlations and help guide interpretation of ictal semiology during pre‐surgical evaluation. PubMed and Embase databases were searched using the following keywords: “fronto‐opercular OR frontal ...
Zeynep Gokce‐Samar, Alexandra Montavont, Marion Comajuan, Julitta de Bellescize, Eleni Panagiotakaki, Marietta Papadopoulou, Matthildi‐Athina Papathanasiou‐Terzi, Joseph Toulouse, Alexis Arzimanoglou, Karine Ostrowsky‐Coste   +9 more
wiley   +1 more source

Informed acceptance and perceptions of the 2025 ILAE seizure classification following structured teaching

Epileptic Disorders, EarlyView.
Abstract Objective To assess informed acceptance and perceptions of the 2025 update of the International League Against Epilepsy (ILAE) seizure classification—after participants had received a focused educational introduction to the updated classification. Methods We analyzed anonymized live poll responses from two educational webinars dedicated to the
Sándor Beniczky, Maša Malenica, Nicola Lawrence, Victoria San Antonio‐Arce, Jessica Norvell, J. Helen Cross, Eugen Trinka   +6 more
wiley   +1 more source

Unsupervised clustering of electroclinical features in temporal lobe epilepsy: A data‐driven approach

Epileptic Disorders, EarlyView.
Abstract Objective To identify clinically meaningful patterns in ictal electroclinical features of focal epilepsy using a data‐driven, unsupervised learning approach, and to assess whether such patterns can localize and lateralize the epileptogenic zone (EZ) more accurately than conventional electroclinical interpretation.
Maria Vlachou, Bernadett Molnár, Helene Kaas, Jesper Tveit, Harald Aurlien, Martin Ejler Fabricius, Guido Rubboli, Lars Hageman Pinborg, Sándor Beniczky   +8 more
wiley   +1 more source

On the Nature of the Knee-Jerk [PDF]

The American Journal of Psychology, 1889
openaire   +2 more sources

The Great-toe Jerk [PDF]

BMJ, 1958
openaire   +2 more sources