Results 101 to 110 of about 53,889 (259)
A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death
Blood Cancer JournalHighlights CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decreases ...
Arghya Ray +19 more
doaj +1 more source
River Research and Applications, EarlyView.ABSTRACT Flow velocity measurement is fundamental to hydrological and hydraulic studies, providing essential data for streamflow estimation and river dynamics analysis. Traditional in situ methods like propeller gauges and acoustic Doppler current profilers are accurate but intrusive and labour‐intensive, while non‐intrusive image processing methods ...
Ghazaleh Nassaji Matin +4 more
wiley +1 more source
Remote Sensing in Ecology and Conservation, EarlyView.This study investigates the integration of synthetic imagery, created with diffusion‐based models, to supplement limited training data and improve muskox (Ovibos moschatus) detection in zero‐shot (ZS) and few‐shot (FS) settings. ZS models detected more than 80% of muskoxen in real images, confirming the potential of synthetic data as a substitute for ...
Simon Durand +4 more
wiley +1 more source
Remote Sensing in Ecology and Conservation, EarlyView.This study evaluates the performances of synchronous aerial visible (VIS) and thermal infrared (TIR) imagery for detecting great blue heron (Ardea herodias) nests and individuals using a YOLO11n model. VIS and TIR images were automatically aligned using deep learning, and both early and late fusion approaches were tested.
Camille Dionne‐Pierre +6 more
wiley +1 more source
Better on Average? Average Inflation Targeting With an Unclear Averaging Window
Southern Economic Journal, EarlyView.ABSTRACT Average inflation targeting (AIT) aims to stabilize inflation expectations by offsetting past deviations from target. However, ambiguity about the averaging window can complicate expectations formation and reduce policy effectiveness. This paper integrates AIT into a benchmark DSGE model, incorporating adaptive learning and a signal extraction
James Dean
wiley +1 more source
TESOL Quarterly, EarlyView.Abstract This qualitative study explores how secondary content‐area teachers of emergent bilingual (EB) students navigate tensions between linguistically responsive professional development (PD) and the implementation of state‐mandated College and Career Readiness (CCR) curricula in south Texas.
Caryn Calisi +8 more
wiley +1 more source
Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma
Nature CommunicationsAnti-CD38 monoclonal antibodies like Daratumumab (Dara) are effective in multiple myeloma (MM); however, drug resistance ultimately occurs and the mechanisms behind this are poorly understood.
Jiye Liu +21 more
doaj +1 more source
immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions
VIEW, EarlyView.The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder +26 more
wiley +1 more source