Interest Clock: Time Perception in Real-Time Streaming Recommendation System [PDF]
User preferences follow a dynamic pattern over a day, e.g., at 8 am, a user might prefer to read news, while at 8 pm, they might prefer to watch movies.
Yongchun Zhu +5 more
semanticscholar +1 more source
SHP2 phosphatase as a novel therapeutic target for melanoma treatment [PDF]
Melanoma ranks among the most aggressive and deadly human cancers. Although a number of targeted therapies are available, they are effective only in a subset of patients and the emergence of drug resistance often reduces durable responses.
Bai, Yunpeng +8 more
core +1 more source
Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis
Circular RNA Ribonuclease P RNA Component H1 (circ_RPPH1) and microRNA (miRNA) miR-1296-5p play a crucial role in breast cancer (BC), but the molecular mechanism is vague.
Jingwu Jiang +6 more
semanticscholar +1 more source
A debris-flow monitoring devices and methods bibliography
International audienceDebris-flow monitoring has two functions, warning and modeling. The warning function includes the following parameters: occurrence prediction and detection, proximity sensing, and discharge-estimation.
Inaba, H., Itakura, Y., Sawada, T.
core +2 more sources
Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis [PDF]
Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is one of the most lethal cancer types, with an estimated 44,330 death in 2018 in the US alone.
Chen, Shaoxiong +8 more
core +1 more source
A high-precision oasis dataset for China from remote sensing images
High-resolution oasis maps are imperative for understanding ecological and socio-economic development of arid regions. However, due to the late establishment and relatively niche nature of the oasis discipline, there are no high-precision datasets ...
Jingwu Lin +5 more
semanticscholar +1 more source
Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression. [PDF]
Purpose: Aggressive pancreatic cancer is commonly associated with a dense desmoplastic stroma, which forms a protective niche for cancer cells. The objective of the study was to determine the functions of tissue transglutaminase (TG2), a Ca2+-dependent ...
Caperell-Grant, Andrea +7 more
core +1 more source
Defective TGFβ signaling in bone marrow-derived cells prevents Hedgehog-induced skin tumors [PDF]
Hedgehog (Hh) signaling in cancer cells drives changes in the tumor microenvironment that are incompletely understood. Here we report that Hh- driven tumors exhibit an increase in myeloid-derived suppressor cells (MDSC) and a decrease in T cells ...
Fan, Qipeng +7 more
core +1 more source
Biophysical Environmental Chemistry: A New Frontier for Chemistry
The paper discusses the position and role of environmental chemistry among the other environmental disciplines. It discusses the various aspects of environmental chemistry and emphasizes the need for developing fundamental studies in biophysical
Jacques Buffle +2 more
doaj +2 more sources
Validation-based insertional mutagenesis (VBIM) technology identifies adenomatous polypossis coli (APC) like protein (ALP) as a novel negative regulator of NF-κB [PDF]
Colorectal cancer (CRC) is the third leading cause of cancer related deaths in the United States. The nuclear factor κB (NF-κB) is an important family of transcription factors whose aberrant activation has been found in many types of cancer, including
Mundade, Rasika S.
core +1 more source

