Results 11 to 20 of about 379,851 (179)

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome. [PDF]

Alzheimers Dement
Abstract INTRODUCTION An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS We analyzed clinical and genetic data from 100
Groeneveld J, Perlaza D, Olivé C, Grangeon L, Tesi N, Nicolas A, Jiang C, de Rojas I, Wallon D, Rousseau S, Rovira M, de Asúa DR, Moldenhauer F, Mu R, Cassinari K, Zarea A, Escabias JA, Lambert JC, Pijnenburg YAL, Hulsman M, Vijverberg EGB, Levin J, Jucker M, McDade E, Fortea J, Holstege H, Duits FH, Vermunt L, Patel M, Johnson M, Renton AE, Goate AM, Cruchaga C, Pottier C, Fernandez MV, Belbin O, Nicolas G, Dols-Icardo O, van der Lee SJ, Dominantly Inherited Alzheimer Network.   +39 more
europepmc   +2 more sources

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease. [PDF]

Eur J Neurosci
Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Martínez-Tazo P, Mejias-Ortega M, López-López V, Bhojwani-Cabrera AM, Saxton E, Canals S, Hardingham G, Gutierrez A, Lopez-Atalaya JP, De Santis S.   +9 more
europepmc   +2 more sources

CSF Biomarker Profile of Cerebral Amyloid Angiopathy: Diagnostic Performance and Imaging Correlates in a Hospital-Based Neurology Cohort. [PDF]

Eur J Neurol
Cerebral amyloid angiopathy (CAA) frequently coexists with Alzheimer's disease (AD), complicating diagnosis in patients with cognitive impairment. In this hospital‐based cohort including healthy controls, CAA, AD, and mixed CAA‐AD cases, CSF Aβ40 and Aβ42 provided complementary diagnostic value for identifying CAA. Lower CSF Aβ40 levels were associated
Fernández-Lebrero A, Jiménez-Balado J, García-Escobar G, Contador J, Estraguès-Gázquez I, Peraferrer-Montesinos L, Suárez-Pérez A, Manero-Borràs RM, Beltrán B, Gramegna L, Campello AR, Palacio-Gili A, Grau O, Suárez-Calvet M, Ois A, Puig-Pijoan A, Navalpotro-Gómez I.   +16 more
europepmc   +2 more sources

Resting-state default mode network connectivity in young individuals with Down syndrome. [PDF]

Brain Behav, 2021
DMN in Down syndrome. Network indicators in DS. Functional connectivity. Abstract Background Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using resting‐state fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure
Figueroa-Jimenez MD, Cañete-Massé C, Carbó-Carreté M, Zarabozo-Hurtado D, Peró-Cebollero M, Salazar-Estrada JG, Guàrdia-Olmos J.   +6 more
europepmc   +2 more sources

Relationship between locus coeruleus and slow-wave sleep in aging and Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations.
Falgàs N, Tort-Colet N, Martín-Sobrino I, Mayà G, Peña-González M, Rudilosso S, Gaig C, Bosch B, Arqueros A, Pérez-Millan A, Tort-Merino A, Fernández-Villullas G, Piñol-Ripoll G, Balasa M, Lladó A, Ruiz MM, Muñoz-Moreno E, Grau-Rivera O, Iranzo A, Grinberg LT, Sánchez-Valle R.   +20 more
europepmc   +2 more sources

Joan Maragall traductor d'Hesíode?

Faventia, 1999
An unknown attempt of metrical translation into Catalan of some passages from the hesiodic Theogony by the poet Joan Maragall and datable from his last years.
Torné Teixidó, Ramón, Torné i Teixidó, Ramon   +1 more
core   +4 more sources

Joan Maragall: Pensamiento y Personalidad.

Anales del Seminario de Historia de la Filosofía, 1997
Sin ...
Maragall Noble, Jordi
openaire   +3 more sources

ChREBP-driven DNL and PNPLA3 Expression Induced by Liquid Fructose are Essential in the Production of Fatty Liver and Hypertriglyceridemia in a High-Fat Diet-Fed Rat Model. [PDF]

Mol Nutr Food Res, 2022
Rats receive a high fat diet with (HFHFr) and without liquid fructose (HFD). At the end of the experiment, body weight is unchanged, due to increased in thermogenesis. There are minor metabolic changes in livers from HFD‐fed rats, while HFHFr fed‐rats show liver steatosis and hypertriglyceridemia.
Velázquez AM, Bentanachs R, Sala-Vila A, Lázaro I, Rodríguez-Morató J, Sánchez RM, Alegret M, Roglans N, Laguna JC.   +8 more
europepmc   +2 more sources

Associations between air pollution and surrounding greenness with internalizing and externalizing behaviors among schoolchildren. [PDF]

Child Adolesc Ment Health
Background Air pollution and greenness are emerging as modifiable risk and protective factors, respectively, in child psychopathology. However, research shows inconsistencies. Here, we examined associations between air pollution and surrounding greenness with internalizing and externalizing behaviors.
Zubizarreta-Arruti U, Bosch R, Soler Artigas M, Cabana-Domínguez J, Llonga N, Carabí-Gassol P, Macias-Chimborazo V, Vilar-Ribó L, Ramos-Quiroga JA, Pagerols M, Prat R, Rivas C, Pagespetit È, Puigbó J, Español-Martín G, Raimbault B, Valentín A, Sunyer J, Foraster M, Gascón M, Casas M, Ribasés M, Alemany S.   +22 more
europepmc   +2 more sources

Una noble i serena afirmació d'independència? Correspondència a l'entorn del comentari filològic d'Eduard Valentí Fiol sobre la gènesi del «Cant espiritual» de Joan Maragall

Haidé, 2015
Mostra de la correspondència generada per la publicació el gener de 1963 de l’estudi filològic d’Eduard Valentí i Fiol sobre la gènesi del «Cant espiritual» de Joan Maragall.
Pere Maragall Mira
doaj   +3 more sources