APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome [PDF]
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS We analyzed clinical and genetic data from 100
Joan Groeneveld +39 more
wiley +2 more sources
Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease [PDF]
European Journal of Neuroscience, Volume 63, Issue 9, May 2026.Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo +9 more
wiley +2 more sources
CSF Biomarker Profile of Cerebral Amyloid Angiopathy: Diagnostic Performance and Imaging Correlates in a Hospital‐Based Neurology Cohort [PDF]
European Journal of Neurology, Volume 33, Issue 5, May 2026.Cerebral amyloid angiopathy (CAA) frequently coexists with Alzheimer's disease (AD), complicating diagnosis in patients with cognitive impairment. In this hospital‐based cohort including healthy controls, CAA, AD, and mixed CAA‐AD cases, CSF Aβ40 and Aβ42 provided complementary diagnostic value for identifying CAA. Lower CSF Aβ40 levels were associated
Aida Fernández‐Lebrero +16 more
wiley +2 more sources
Resting‐state default mode network connectivity in young individuals with Down syndrome [PDF]
Brain and Behavior, Volume 11, Issue 1, January 2021., 2021 DMN in Down syndrome. Network indicators in DS. Functional connectivity. Abstract Background Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using resting‐state fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure
María Dolores Figueroa‐Jimenez +6 more
wiley +2 more sources
Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease [PDF]
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations.
Neus Falgàs +20 more
wiley +2 more sources
Associations between air pollution and surrounding greenness with internalizing and externalizing behaviors among schoolchildren [PDF]
Child and Adolescent Mental Health, Volume 30, Issue 2, Page 149-158, May 2025.Background Air pollution and greenness are emerging as modifiable risk and protective factors, respectively, in child psychopathology. However, research shows inconsistencies. Here, we examined associations between air pollution and surrounding greenness with internalizing and externalizing behaviors.
Uxue Zubizarreta‐Arruti +22 more
wiley +2 more sources
Risk of cognitive decline progression is associated to increased blood‐brain‐barrier permeability: A longitudinal study in a memory unit clinical cohort [PDF]
Alzheimer's &Dementia, Volume 20, Issue 1, Page 538-548, January 2024.Abstract INTRODUCTION This study examined the relationship between blood‐brain‐barrier permeability (BBBp), measured by cerebrospinal fluid/serum albumin ratio (QAlb), and cognitive decline progression in a clinical cohort. METHODS This prospective observational study included 334 participants from the BIODEGMAR cohort.
Albert Puig‐Pijoan +14 more
wiley +2 more sources
Comunicacions del Symposium El pensament de Joan Maragall
, 2010 Recull de sis comunicacions sobre temes específics del pensament de MaragallEl pensament de Maragall és / Jaume Trabal; La poètica de Maragall en la filosofia d'Eugeni d'Ors i de Francesc Pujols / Joan Cuscó i Clarasó; Entre la paraula i el silenci ...
Trabal, Jaume +5 more
core +3 more sources
El Cant espiritual, ¿summa final o llindar d'un nou camí?
, 2010 Pere Maragall, professor de literatura catalana i nét de Joan Maragall, parla del perquè del seu interès per la figura de Joan Maragall, comenta alguns punts de la seva evolució personal i analitza el rerefons del Cant Espiritual en un intent de ...
Maragall i Mira, Pere
core +3 more sources
Joan Maragall en l'obra de Joan Perucho
Haidé, 2021 L’obra de Joan Perucho es caracteritza per una abundant transtextualitat amb la inclusió de nombroses referències i citacions de textos de tota mena, i de diversa procedència, no sempre literària.
Pere Torra
doaj +1 more source