Results 101 to 110 of about 1,864,454 (302)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Application of Text Mining and K-Medoids for Job Clustering Based on Job Description Analysis

Jurnal Teknologi dan Manajemen Informatika
The massive growth of job description data poses challenges in manual job classification due to the unstructured nature of the data. This study aims to develop a job cluster grouping model using a text mining approach and the K-Medoids algorithm.
Teguh Aries Wahyudi, Amaludin Arifia, Andik Adi Suryanto   +2 more
doaj   +1 more source

PERANCANGAN LOWONGAN KERJA ONLINE BERBASIS WEB PADA PT ANH

Jurnal Ilmiah Informatika, 2017
Internet technology is currently growing, as well as the flow of communication in the delivery of employment information provided or required by various parties, including government and private.
Akhsani Taqwiym, Novan Wijaya
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Do anonymous job application procedures level the playing field? [PDF]

Anonymous application procedures (AAP) are increasingly promoted as a way to combat employment discrimination. The idea gets support from theory and experimental evidence, but virtually nothing is known about its real-life effects.
Nordström Skans, Oskar, Åslund, Olof
core  

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Factors influencing the acceptance and use of a South African data-free job search application

South African Journal of Information Management
Background: Despite the rise of digital job search tools, many South Africans remain excluded due to connectivity and financial barriers. The digital divide, particularly among youth and low-income groups, limits access to job opportunities, exacerbated ...
Tsholofelo Mangadi, Fazlyn Petersen
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

The Effect of Job Mutation, Work Rotation on Performance with Job Satisfaction as an Intervening Variable in PLN UP3 Situbondo

Indonesian Interdisciplinary Journal of Sharia Economics
In the competitive global economy, optimizing human resource performance is crucial. Organizations frequently utilize job transfer and rotation policies to enhance adaptability and skills, yet their impact on employee performance remains inconsistent ...
Hotber Joy Hamonangan Sitanggang, Sugeng Mulyono, Jamal Abdul Nasir   +2 more
doaj   +1 more source