Results 101 to 110 of about 6,401,403 (305)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 1919 The four sons of Thomas Raffles Job and Agnes Beater Brown who were active in Job Brothers & Co. between 1886 and 1952.This collection consists of photographs taken from two Job family albums, reflecting their business ventures, family activities and ...
Job, John (William John), b. 1944-
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Worker characteristics, job characteristics, and opportunities for phased retirement [PDF]
Labour Economics, 2007 Abstract This paper uses a telephone survey of 950 employers to examine employer-side restrictions on phased retirement. The survey not only collected information on establishment level policies, but it also asked questions about a specific worker's opportunity for phased retirement.
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Work alienation among young university teachers in China
Frontiers in PsychologyIntroductionYoung university teachers in China often begin their careers under competitive employment arrangements that combine intensive teaching and research demands with uncertain prospects for long-term advancement.MethodsUsing cross-sectional survey
Jing Li, Danlei Lin, Tingting Chang
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
NEGATIVE AFFECTIVITY, CONSCIENTIOUSNESS AND JOB SCOPE (A CASE OF IT AND TELECOM INDUSTRY) [PDF]
Annals of the University of Petrosani: Economics, 2010 Based on a sample of 350 employees in the telecommunication and telecommunication, we obtained empirical evidence suggesting that while individuals high on conscientiousness tended to react more positively to job scope, individuals high on negative ...
BILAL AFSAR +2 more
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
, 1905 A view of a booth displaying products that were produced or distributed by Job Brothers & Co.This collection consists of photographs taken from two Job family albums, reflecting their business ventures, family activities and historical ...
Job, John (William John), b. 1944-
core