Results 71 to 80 of about 256,057 (263)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The association of workplace psychosocial factors on premenstrual dysphoric disorder: A six‐month prospective study on Japanese female workers

PCN Reports
Aim This study examined the longitudinal associations between psychosocial factors in the workplace and the emergence of premenstrual dysphoric disorder (PMDD) symptoms among Japanese female workers, with a particular focus on psychological distress as a
Mako Iida, Kazuhiro Watanabe, Miho Egawa, Yuka Ito, Yoshiaki Kanamori, Rikako Tsuji, Daisuke Nishi, Natsu Sasaki   +7 more
doaj   +1 more source

The influence of multiple occupational exposures on absence from work in pregnancy: a prospective cohort study

Scandinavian Journal of Work, Environment & Health, 2020
OBJECTIVES: Many women experience absence periods from work during pregnancy. Several single risk factors for absence are identified, whereas the impact of multiple concurrent exposures has been sparsely studied.
Camilla Sandal Sejbaek, Jacob Pedersen, Vivi Schlünssen, Luise Mølenberg Begtrup, Mette Juhl, Jens Peter Bonde, Petter Kristensen, Hans Bay, Cecilia Høst Ramlau-Hansen, Karin Sørig Hougaard   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Do working conditions explain the increased risks of disability pension among men and women with low education? A follow-up of Swedish cohorts

Scandinavian Journal of Work, Environment & Health, 2014
OBJECTIVES: Rates of disability pension are greatly increased among people with low education. This study examines the extent to which associations between education and disability pensions might be explained by differences in working conditions ...
Daniel Falkstedt, Mona Backhans, Andreas Lundin, Peter Allebeck, Tomas Hemmingsson   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The relationship of job demands, job control with job stress, positive affect and negative affect among employees

پژوهش‌های علوم شناختی و رفتاری, 2013
The main purpose of this research was to examine the relationship between job demands, job control and job stress, positive affect and negative affect. The research method was correlational.
S. Jahanbakhsh Ganjeh, H. R. Oraizy Samani   +1 more
doaj  

Effect Modification by Attention Deficit Hyperactivity Disorder (ADHD) Symptoms on the Association of Psychosocial Work Environments With Psychological Distress and Work Engagement

Frontiers in Psychiatry, 2019
Objective: The aim of this study was to examine how attention-deficit hyperactivity disorder (ADHD) symptoms play an interaction effect on the association between psychosocial work environments and health (psychological distress/work engagement) among ...
Masako Nagata, Masako Nagata, Tomohisa Nagata, Akiomi Inoue, Koji Mori, Shinya Matsuda, Shinya Matsuda   +6 more
doaj   +1 more source

Low Job Control and Racial Disparities in Breastfeeding. [PDF]

J Occup Environ Med, 2022
Whitley MD, Ro A, Choi B.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source