Results 91 to 100 of about 1,998,863 (253)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Organisational climate and its effect on job engagement: exploring the mediating effect of employees level of job satisfaction [PDF]
, 2013 This study examined two under-researched organisational climate facets, integration and family-focused supervisor support, as predictors of employees' job engagement.
Koch, Timothy C
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Relationship between Job Motivation, Job Involvement and Organizational Commitment of Teachers and Managers΄ Productivity in Education Administration of Zanjan [PDF]
مدیریت بهره وری, 2015 A person who suffers from low job motivation usually goes to work with reluctance and delay, and he has no desire to perform well.The present study aims to determine the relationship between job motivation, job involvement, and organizational commitment ...
Gholamhosein Entesar foomani
doaj
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Pengaruh Job Demands, Job Resources, Dan Job Involvement Terhadap Job Satisfaction
Lokawati : Jurnal Penelitian Manajemen dan Inovasi RisetThis study aims to examine and analyze the effect of job demands, job resources, and job involvement on employee job satisfaction. Job demands affect job satisfaction, job resources affect job satisfaction, and job involvement affects job satisfaction. The population in this study were employees of the Department of Tourism, Youth and Sports, Magelang ...
null Muhamad Izdad Fuadi +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Innovativeness and consumer involvement in the Chinese market [PDF]
, 2006 There are many markets where two technologies co-exist and compete and predicting consumer choice in this situation is difficult. Existing theories such as the diffusion of innovation go some way to explaining the initial take up of the new technology ...
Hynes, N., Lo, S.
core +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source