Results 81 to 90 of about 1,998,863 (253)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Influence of Performance Appraisal Challenges Facing Nurses on their Job Involvement [PDF]

Tanta Scientific Nursing Journal
Background: Performance appraisal challenges are obstacles that hinder fairevaluation, including appraiser bias, unclear criteria, and inadequate feedback.
Rehab Abou Shaheen, Amal Abou Ramadan, Doha Ramadan   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of correlation between job involvement and occupational quality of life of nursing interns and its influencing factors

Huli yanjiu, 2017
Objective:To probe into the correlation between job involvement and occupational quality of life of nursing interns during internship and analyze influencing factors of job involvement,so as to improve work efficiency and input of nursing interns,and to ...
龙春鹂, 李海燕, 钱火红
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pengaruh Modal Psikologi Dan Keterlibatan Pegawai Terhadap Kinerja Pegawai Dengan Kepuasan Kerja Sebagai Variabel Mediasi (Studi Pegawai Politeknik Ilmu Pelayaran Semarang)

Jurnal Manajemen Teori dan Terapan, 2016
The research objective to be achieved to analyze the effect of psychological capital and employee involvement to job satisfaction in Seamanship Polytechnic Semarang. To analyze the effect of psychological capital, employee engagement and job satisfaction
Adhi Prastistha Silen
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The prediction of job involvement for pharmacists and accountants

SA Journal of Industrial Psychology, 2003
The job involvement of the individual seems to be potentially fundamental to the satisfaction of certain salient psychological needs that could lead to positive organizational implications. This study investigates the predictiveness of job involvement of
R. Van Wyk, A. B. Boschoff, F. V. N. Cilliers   +2 more
doaj   +1 more source

Workers’ Involvement at the Workplace and Job Quality in Europe

SSRN Electronic Journal, 2009
The paper focuses on workplace practices aimed at increasing workers’ direct voice, a job quality dimension in the European Employment Strategy for which there are no agreed indicators. It offers an analysis of the theories, debate and research on the impact of workers’ direct participation on jobs’ quality and quantity, including its interaction and ...
openaire   +3 more sources

A Study for the Relationship between Job Involvement and Cohesion for Public Psychiatric Hospital?s Employee

, 2009
[[abstract]]Due to the pressure of the cost, the public psychiatric hospitals of the Department of Healthy, Executive Yuan, had accept no more official job, and many non-organizational staff were adopted.
Feng-Chaio Li
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