Results 71 to 80 of about 1,335 (194)

Lifelong Evolution of Autoreactive Plasma Cell Numbers, Affinity, and Anatomic Location in Arthritic K/BxN Mice

Arthritis &Rheumatology, EarlyView.
Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Thibault Vanhoucke, Carlos Castrillon, Odile Richard‐Le Goff, Angga Perima, Matteo Broketa, Andrew D. Griffiths, Patrick England, François Huetz, Pierre Bruhns   +8 more
wiley   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Mindfulness and resilience: The experiences of global majority students in a mindfulness intervention Programme at a UK university

British Educational Research Journal, EarlyView.
Abstract Wellbeing in higher education (HE) in the United Kingdom has been increasingly prioritised for many institutions, with a growing demand for student support requests. There are various determinants in life that can influence mental health. As such, protected characteristics, including race, can indicate that students who are Black or Asian ...
Amy Bywater, Helen Keane
wiley   +1 more source

Enablers of community-led action in Australian climate disasters: recognising the role of pre-existing social foundations and local knowledges. [PDF]

Disasters
Webster S, Schlosberg D, Longman J, Pittaway E, Gillies-Palmer Z, Verlie B, Bailie J, Celermajer D, Howard A, Matous P, Naderpajouh N, Viney G, Iveson K, Joseph P, Rawsthorne M, Troy J.   +15 more
europepmc   +1 more source

Inequitable paediatric kidney transplantation in resource-limited countries: expert recommendations for Nigeria - a scoping review. [PDF]

BMJ Glob Health
Anigilaje EA, Oni L, Adedoyin OT, Eke FU, Okafor H, Odetunde OI, Ibitoye PK, Ademola AD, Alao MA, Oniyangi O, Obiagwu PN, Adetunji AE, Ajite BA, Adaje AO, Ajetomobi A, Mark F, Briggs DC, Epundu N.   +17 more
europepmc   +1 more source

Controlling the Field: Memory, Labor, and Ethics in Oral Histories of Brazilian Human Genetics

Berichte zur Wissenschaftsgeschichte, EarlyView.
This article examines how oral histories of twentieth‐century human genetics in Brazil reveal the politics of memory of fieldwork. Through a comparative analysis of interviews with prominent geneticist Francisco M. Salzano and technician Girley V. Simões, who worked with him for most of his career, this study explores the narrative strategies each ...
Rosanna Dent, Ana Carolina Vimieiro Gomes   +1 more
wiley   +1 more source

Kun-peng enables scalable and accurate pan-domain metagenomic classification. [PDF]

Brief Bioinform
Chen Q, Zhang B, Peng C, Huang J, Liu Z, Shen X, Jiang C.   +6 more
europepmc   +1 more source

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Utilizing a steering committee to implement Health in All Policies in a rural, micro-urban community. [PDF]

Health Promot Int
Comey DL, Hanson BL, Neavill ME, Church SP, MacFarlane J, Madsen M.   +5 more
europepmc   +1 more source

An automated microfluidic biosensor with bispecific rabbit monoclonal antibody and nanozyme‐bioenzyme composite for dual antibiotic detection

BMEMat, EarlyView.
This study introduces an automated microfluidic biosensor for simultaneous detection of florfenicol and thiamphenicol in environmental water. By integrating a phage‐screened bispecific rabbit monoclonal antibody with a nanozyme‐bioenzyme composite, the system achieves sensitive dual‐antibiotic detection. Coupled with smartphone‐based sensing, it offers
Fuyuan Zhang, Yang Liu, Juntao Wang, Haichao Zhang, Wenlong Yu, Yaxin Sang, Yun Liu, Guangze Yang, Fang Gao, Shuo Wang, Shilun Feng, Xianghong Wang   +11 more
wiley   +1 more source