Results 51 to 60 of about 28,243 (317)
Molecular Oncology, EarlyView.Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores +14 more
wiley +1 more source
Matrix: Jurnal Manajemen Teknologi dan Informatika, 2016 Job shop atau yang dikenal juga dengan istilah shop floor control merupakan salah satu metode penyusunan jadwal produksi yang rumit. Beberapa faktor penyebab rumitnya penyusunan jadwal menggunakan metode job shop adalah banyaknya jumlah variasi produk ...
Ida Bagus Putra Manuaba
doaj
An Improved Shuffled Frog-Leaping Algorithm for Flexible Job Shop Scheduling Problem
Algorithms, 2015 The flexible job shop scheduling problem is a well-known combinatorial optimization problem. This paper proposes an improved shuffled frog-leaping algorithm to solve the flexible job shop scheduling problem. The algorithm possesses an adjustment sequence
Kong Lu +5 more
doaj +1 more source
Dynamic Data Scheduling of a Flexible Industrial Job Shop Based on Digital Twin Technology
Discrete Dynamics in Nature and Society, 2022 Aiming at the problems of premature convergence of existing workshop dynamic data scheduling methods and the decline in product output, a flexible industrial job shop dynamic data scheduling method based on digital twin technology is proposed.
Juan Li, Xianghong Tian, Jing Liu
doaj +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
The Effects of Machine Load Sitnations on Performance of Job Shop and Group Scheduling
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 1998 Perfonnance of job shop and group scheduling ndermultinatch work input environment was exarnined against two nachine load (light and high load) situations.
O.TORKUL TORKUL
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Molecular Oncology, EarlyView.Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara +14 more
wiley +1 more source
Research on steady-state simulation in dynamic job shop scheduling problem
Advances in Mechanical Engineering, 2015 A systematic research of steady state for the dynamic job shop scheduling problem with jobs releasing continuously over time has been conducted in this article.
Hegen Xiong +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source