Results 51 to 60 of about 24,116 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
PEMAKAIAN ALGORITMA GENETIK UNTUK PENJADWALAN JOB SHOP DINAMIS NON DETERMINISTIK
Jurnal Teknik Industri, 2004 Dynamic Job shops non deterministic scheduling problem is concerned with ordering some operations that processed by certain machines with variable and unknown arrival time of jobs. When new jobs arrive, it requires modifications in the existing schedule.
Nico Saputro, Yento Yento
doaj
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Jurnal Ilmiah Teknik Industri, 2005 This paper develops job shop production scheduling using Non Delay algorithm through forward and backward-forward algorithm to minimize total earliness and tardiness costs.
Dian Retno Sari Dewi
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An effective hybrid algorithm for multi-objective flexible job-shop scheduling problem
Advances in Mechanical Engineering, 2018 Genetic algorithm is one of primary algorithms extensively used to address the multi-objective flexible job-shop scheduling problem. However, genetic algorithm converges at a relatively slow speed.
Xiabao Huang, Zailin Guan, Lixi Yang
doaj +1 more source
A Dynamic Adjusted Aggregate Load Method to Support Workload Control Policies
Applied Sciences, 2020 Workload control mechanisms are widely studied in the literature for the control of job-shop systems. The control of these systems involves acceptance, order release and priority dispatching.
Paolo Renna
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A hybrid algorithm for flexible job-shop scheduling problem with setup times
International Journal of Production Management and Engineering, 2017 Job-shop scheduling problem is one of the most important fields in manufacturing optimization where a set of n jobs must be processed on a set of m specified machines.
Ameni Azzouz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source