Results 61 to 70 of about 1,132,012 (246)

PENGEMBANGAN ALGORITMA PENJADUALAN PRODUKSI JOB SHOP UNTUK MEMINIMUMKAN TOTAL BIAYA EARLINESS DAN TARDINESS

open access: yesJurnal Ilmiah Teknik Industri, 2005
This paper develops job shop production scheduling using Non Delay algorithm through forward and backward-forward algorithm to minimize total earliness and tardiness costs.
Dian Retno Sari Dewi
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

An effective hybrid algorithm for multi-objective flexible job-shop scheduling problem

open access: yesAdvances in Mechanical Engineering, 2018
Genetic algorithm is one of primary algorithms extensively used to address the multi-objective flexible job-shop scheduling problem. However, genetic algorithm converges at a relatively slow speed.
Xiabao Huang, Zailin Guan, Lixi Yang
doaj   +1 more source

A Dynamic Adjusted Aggregate Load Method to Support Workload Control Policies

open access: yesApplied Sciences, 2020
Workload control mechanisms are widely studied in the literature for the control of job-shop systems. The control of these systems involves acceptance, order release and priority dispatching.
Paolo Renna
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A hybrid algorithm for flexible job-shop scheduling problem with setup times

open access: yesInternational Journal of Production Management and Engineering, 2017
Job-shop scheduling problem is one of the most important fields in manufacturing optimization where a set of n jobs must be processed on a set of m specified machines.
Ameni Azzouz   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Does Order Negotiation Improve The Job-Shop Workload Control? [PDF]

open access: yes
Work flows in a job-shop are determined not only by the release load and the time between release factors, but also by the number of accepted orders.
M. Rosário Moreira, Rui Alves
core  

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