Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Research on steady-state simulation in dynamic job shop scheduling problem
Advances in Mechanical Engineering, 2015 A systematic research of steady state for the dynamic job shop scheduling problem with jobs releasing continuously over time has been conducted in this article.
Hegen Xiong +3 more
doaj +1 more source
Dynamic Data Scheduling of a Flexible Industrial Job Shop Based on Digital Twin Technology
Discrete Dynamics in Nature and Society, 2022 Aiming at the problems of premature convergence of existing workshop dynamic data scheduling methods and the decline in product output, a flexible industrial job shop dynamic data scheduling method based on digital twin technology is proposed.
Juan Li, Xianghong Tian, Jing Liu
doaj +1 more source
Scheduling of non-repetitive lean manufacturing systems under uncertainty using intelligent agent simulation [PDF]
, 2008 World-class manufacturing paradigms emerge from specific types of manufacturing systems with which they remain associated until they are obsolete. Since its introduction the lean paradigm is almost exclusively implemented in repetitive manufacturing ...
Mousavi, A, Papadopoulou, T C
core +1 more source
A hybrid shifting bottleneck-tabu search heuristic for the job shop total weighted tardiness problem [PDF]
, 2010 In this paper, we study the job shop scheduling problem with the objective of minimizing the total weighted tardiness. We propose a hybrid shifting bottleneck - tabu search (SB-TS) algorithm by replacing the reoptimization step in the shifting bottleneck
Bulbul, Kerem, Bülbül, Kerem
core +5 more sources
Critical Review on the Objective Function of Flexible Job Shop Scheduling [PDF]
, 2022 Fengque Pei +3 more
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Capacity Planning and Leadtime management [PDF]
, 1996 In this paper we discuss a framework for capacity planning and lead time management in manufacturing companies, with an emphasis on the machine shop. First we show how queueing models can be used to find approximations of the mean and the variance of ...
Buitenhek, R., Zijm, W.H.M.
core +2 more sources
An Adaptive Reinforcement Learning-Based Scheduling Approach with Combination Rules for Mixed-Line Job Shop Production [PDF]
, 2022 Haihua Zhu +3 more
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source