Results 61 to 70 of about 122,671 (350)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Intelligent Scheduling with Reinforcement Learning
Applied Sciences, 2021 In this paper, we present and discuss an innovative approach to solve Job Shop scheduling problems based on machine learning techniques. Traditionally, when choosing how to solve Job Shop scheduling problems, there are two main options: either use an ...
Bruno Cunha +3 more
doaj +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
An effective hybrid algorithm for multi-objective flexible job-shop scheduling problem
Advances in Mechanical Engineering, 2018 Genetic algorithm is one of primary algorithms extensively used to address the multi-objective flexible job-shop scheduling problem. However, genetic algorithm converges at a relatively slow speed.
Xiabao Huang, Zailin Guan, Lixi Yang
doaj +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
FEBS Open Bio, EarlyView.PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley +1 more source
Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach
FEBS Open Bio, EarlyView.This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma +10 more
wiley +1 more source
Heuristics for Job-Shop Scheduling [PDF]
, 1988 Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1988.
openaire +2 more sources
Optimization based job shop scheduling [PDF]
IEEE Transactions on Automatic Control, 1993 Summary: A generalized job shop scheduling problem is defined in detail. The proposed factory description is sufficiently realistic to model the routing and sequencing decisions made in a real manufacturing plant. An optimization problem is posed, permitting the use of very general cost functions.
K.L. Musser +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source