Results 61 to 70 of about 67,577 (216)

Job satisfaction and turnover intentions among health care staff providing services for prevention of mother-to-child transmission of HIV in Dar es Salaam, Tanzania

Human Resources for Health, 2017
Background Option B+ for the prevention of mother-to-child transmission (PMTCT) of HIV (i.e., lifelong antiretroviral treatment for all pregnant and breastfeeding mothers living with HIV) was initiated in Tanzania in 2013.
Helga Naburi, Phares Mujinja, Charles Kilewo, Nicola Orsini, Till Bärnighausen, Karim Manji, Gunnel Biberfeld, David Sando, Pascal Geldsetzer, Guerino Chalamila, Anna Mia Ekström   +10 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Emotional Stability and Perception of Job Security in the Services Sector in Malaysia

Malaysian Management Journal, 2004
Research pertaining to the perception of job security has focused primarily on attitudinal (e.g. job satisfaction), behavioral (e.g. employee turnover), and health outcomes, while research in the area of emotional stability has largely focused on ...
Kamarul Zaman Ahmad, Nor Khasimah Aliman, Nurul Shanaz Ahmad Mahdzan, Maria Azlina Kamarudin, Chow Yee Peng, Tusha Nandita   +5 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Influence of psychological capital and personality traits on job burnout of nursing staff

Huli yanjiu, 2018
Objective:To probe into the influence of psychological capital and personality traits on job burnout of nursing staff.Methods:A total of 400 nursing staff in affiliated hospital of Jining medical university were investigated by eysenck personality ...
王忠云, 李甜甜, 何燕, 刘永闯
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Influence of job satisfaction, job stress, job identity and job values on turnover intention among male physician assistant nurses MZ generation nurses in South Korea [PDF]

Journal of Men's Health
Background: Turnover intention among nursing professionals is a critical issue impacting healthcare workforce stability and patient care quality. However, research specifically focusing on male physician assistant nurses (PAs) remains limited.
Myeong Jong Kim, Sun Jung Park, Youngsook Lim, Hana Cho, Hyunji Kim   +4 more
doaj   +1 more source

Felicidad: análisis de drivers entre Chile y Canadá

Estudios de Administración, 2011
This study attempts to assess the relative importance of different drivers of happiness and their impact in the subjective well being of individuals. It tries to measures factors and conditions that make people report a higher level of happiness.
Miguel Mendoza H., Benjamín Gómez C.
doaj   +1 more source