Results 21 to 30 of about 6,752,846 (254)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
“… God Said”: Toward a Quantum Theology of Creation
Open TheologyThis work argues that because Quantum Mechanics (QM) is superb at simulating natural, physical phenomena, so-called quantum-native phenomena, and that Quantum Natural Language Processing (QNLP), its child, is also quantum-native, God’s generative ...
Walton Ryder Dale
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Ethical Principles of “Abiding In” from John’s Perspective
Diligentia: Journal of Theology and Christian EducationJohannine Literature is known for its rich theological perspective. Grounding from his theological standpoints, he draws his ethical principles. One of the disputes in this book is whether John has explicit or implicit ethical implications for his ...
Cathryne Berliana Nainggolan
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Letter from John Buchanan-Brown to John Betjeman, December 05, 1960
, 1960 Correspondence between John Betjeman and John Buchanan-Brown.
Buchanan-Brown, John
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Letter from John Lennon to Hagan
, 1927 Holograph letter from John Lennon, Great Southern Hotel, Mallaranny (County Mayo), to Hagan. Remarks about the slow journey, the pleasant situation on Clew Bay.
core +3 more sources
New challenges in diagnosis of haemoglobinopathies: Migration of populations
Thalassemia Reports, 2018 The current influx of economic migrants and asylum seekers from countries with a high prevalence of haemoglobinopathies creates new challenges for health care systems and diagnostic laboratories.
John Old +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source