Results 31 to 40 of about 6,752,846 (254)

Letter from John Lennon to Hagan

open access: yes, 1928
Holograph letter from John Lennon, the Presbytery, Portarlington (County Laois), to Hagan, enclosing copy typescript will and probate of Fr. Matthew Lawlor, Portarlington (Solicitor John Foley); appointing Frs. M. Cullen and L.J. Kehoe executors; leaving

core   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

AFRICA AND THE EXPANSION OF INTERNATIONAL SOCIETY: SURRENDERING THE SAVANNAH

open access: yesUluslararası Ekonomi, İşletme ve Politika Dergisi, 2021
Bu çalışmada 2015 yılında yayımlanmış John Anthony Pella,'ya ait "Africa and the Expansion of International Society: Surrendering the Savannah" adlı kitap incelenmiştir.
Murat Poyraz
doaj  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

The power of Logos in human rationality and its relevance in the modern era of science

open access: yesKamasean
The concept of the Logos in the Gospel of John has long been the subject of theological and philosophical discussions. In the era of modern science, questions have arisen about the relevance and relationship between this concept of the Logos and the ...
risno tampilang
doaj   +1 more source

Control of sulfur partitioning between primary and secondary metabolism in Arabidopsis

open access: yesFrontiers in Plant Science, 2012
Sulfur is an essential nutrient for all organisms. Plants are able to take up inorganic sulfate and assimilate it into a range of bioorganic molecules either after reduction to sulfide or activation to 3’-phosphoadenosine 5’-phosphosulfate.
Stanislav eKopriva   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

open access: yesFEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar   +11 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

open access: yesFEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan   +2 more
wiley   +1 more source

John and the Synoptic Gospels. What John Knew and What John Used

open access: yesPerichoresis: The Theological Journal of Emanuel University
The relationship of John’s Gospel to the Synoptics Gospels is difficult to explain. That is the reason why there have been many proposals, even from the beginning of the church. Not even today, scholars have reached consensus.
Mihăilă Corin
doaj   +1 more source

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