Results 21 to 30 of about 17,410 (218)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Numerical and experimental investigation of Johnson–Cook material models for aluminum (Al 6061-T6) alloy using orthogonal machining approach

Advances in Mechanical Engineering, 2018
This research focuses on the study of the effects of processing conditions on the Johnson–Cook material model parameters for orthogonal machining of aluminum (Al 6061-T6) alloy.
Sohail Akram, Syed Husain Imran Jaffery, Mushtaq Khan, Muhammad Fahad, Aamir Mubashar, Liaqat Ali   +5 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Experimental and Numerical Investigation of Strain Rate Dependent Flow and Fracture Behavior of 6181A-T4 Alloy Using the Johnson–Cook Model

Crystals
The use of aluminum alloys for lightweighting in the automotive industry is becoming widespread. In this study, Johnson–Cook plasticity and damage model parameters were determined to predict the plasticity and damage behavior of 6181A-T4 sheet material ...
Ecenur Öztürk, Onur Cavusoglu, Ahmet Güral   +2 more
doaj   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Fragmentation of armor piercing steel projectiles upon oblique perforation of steel plates

EPJ Web of Conferences, 2012
In this study, a constitutive strength and failure model for a steel core of a14.5 mm API projectile was developed. Dynamic response of a projectile steel core was described by the Johnson-Cook constitutive model combined with principal tensile stress ...
Aizik F., Ran E., Vizel A., Weiss A., Paris V.   +4 more
doaj   +1 more source

A Comparative Study of Three Constitutive Models concerning Thermo-Mechanical Behavior of Q345 Steel during Hot Deformation

Crystals, 2022
The Gleeble-3800 thermal simulator was used to perform hot compression experiments on Q345 steel at a temperature of 1123~1373 K, a strain rate of 0.01~10 s−1, and 60% deformation.
Guanghui Zhao, Yinghao Tian, Yaohui Song, Juan Li, Huaying Li, Jian Zhang   +5 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Comparison of Machining Simulations of Aerospace Alloy Al6061-T6 Using Lagrangian and Smoothed Particle Hydrodynamics Techniques

Lubricants, 2022
This research focuses on the study of the simulation capabilities of the lagrangian (LAG) model and Smoothed Particle Hydrodynamics (SPH) model for the orthogonal dry machining of aluminum alloy Al6061-T6.
Muhammad N. Nawaz, Sohaib Z. Khan, Muhammad Asif, Abdulrahman Aljabri, Asad A. Zaidi, Essam R. I. Mahmoud   +5 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source