Results 71 to 80 of about 2,093,284 (296)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Text of the Ebla Administrative Account TM.75.G.1443+4287 (ARET I 3 + ARET XII 146)
Asia Anteriore AnticaThis article reconstructs an administrative text from two large fragments published in two different volumes of the ARET series: Archivi Reali di Ebla. Testi I, text 3, and Archivi Reali di Ebla. Testi XII, text 146.
Amalia Catagnoti
doaj +1 more source
The socio-political bases of willingness to join environmental NGOs in China: a study in social cohesion [PDF]
This article examines willingness to join China’s emerging green movement through an analysis of data from the China General Social Survey of 2006. A question asked about environmental NGO membership shows that whilst only one per cent of respondents ...
Munro, N.
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Scientific ReportsTo address the prediction and allocation challenges of emergency medical supplies during the middle and late stages of major outbreaks, we proposed an end-to-end ICSL deep learning algorithm architecture.
Yanzhi Pang +10 more
doaj +1 more source
"Intelligent" controllers on cheap and small programmable devices
It is shown that the "intelligent" controllers which are associated to the recently introduced model-free control synthesis may be easily implemented on cheap and small programmable devices.
Chaxel, Frédéric +2 more
core +2 more sources
BMJ, 1998 Join us. And celebrate. You deserve it. You've worked hard, you've passed, and you've got a lot to be proud of. So bring your mum and dad if you want. And your wife or your husband and your kids too if you've got any. There's a bit of a ceremony, an informal supper, and a big welcome for all our new members and their families. Be great to see you all.
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source