Results 71 to 80 of about 60,656 (299)

SWOT Analysis of Pakistan’s Space Program

open access: yesNUST Journal of International Peace and Stability, 2020
Outer space in Pakistan is a trivial notion, and the idea has become less concerning for the authorities let alone the general masses. For decades, this field has been void of any particularly outstanding and significant development in the country
Noor-ul-Huda Atif
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Conjunctive Join-semilattices

open access: yes, 2021
A join-semilattice L with top is said to be conjunctive if every principal ideal is an intersection of maximal ideals. (This is equivalent to a first-order condition in the language of semilattices.) In this paper, we explore the consequences of the ...
Ighedo, Oghenetega   +2 more
core   +1 more source

On spatiality in Tartu–Moscow cultural semiotics: The semiotic subject

open access: yesSign Systems Studies, 2007
The article views the development of the Tartu–Moscow semiotic school from the analysis of texts to the study of spatial entities (semiosphere being most well known of them).
Anti Randviir
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

On Atanassov's intuitionistic fuzzy grade of the direct product of two hypergroupoids

open access: yesKuwait Journal of Science, 2014
In this paper we continue the study of the sequences of join spaces and Atanassov's intuitionistic fuzzy sets associated with the direct product of two hypergroupoids with special properties and we determine the Atanassov's intuitionistic fuzzy grade of ...
BIJAN DAVVAZ, E. HASSANI SADRABADI
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Contact join-semilattices

open access: yes, 2021
Contact algebra is one of the main tools in region-based theory of space. In \cite{dmvw1, dmvw2,iv,i1} it is generalized by dropping the operation Boolean complement. Furthermore we can generalize contact algebra by dropping also the operation meet. Thus
Ivanova, Tatyana
core   +1 more source

Services and Collections Gathered Near the User: Helsinki University Library and its Present Building Projects

open access: yesLiber Quarterly: The Journal of European Research Libraries, 2000
As the National Library of Finland, founded 1640, the Helsinki University Library requires adequate space and this is something we have lacked for the last 60 years.
Dorrit Gustafsson
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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