Results 41 to 50 of about 1,296,860 (280)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transposition Hypergroups: Noncommutative Join Spaces

Journal of Algebra, 1997
A transposition hyperqroup is a hypergroup \(H\) for which: \((b\setminus a)\cap(c/d)\neq\emptyset\) implies \(ad\cap bc\neq\emptyset\), for every \(a\), \(b\), \(c\), \(d\) in \(H\), where \(b\setminus a=\{x\in H\mid a\in bx\}\) and \(c/d=\{x\in H\mid c\in xd\}\). Introducing this notion, the author treats from a unique point of view several algebraic
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Welcome to the Neighborhood: Assessing Localized Social Media Use and Pro-Community Attitudes in a Multi-National Survey

Social Media + Society
In the void left by struggling local media, localized social media systems have proliferated on the web as key avenues for the exchange of location-specific information. Yet, as local ecosystems shift, there is a need to understand the types of audiences
Marianne Aubin Le Quéré, Sanjay R. Kairam   +1 more
doaj   +1 more source

Assessing the significance of first place and online third places in supporting Malaysian seniors’ well-being during the pandemic

Humanities & Social Sciences Communications, 2023
The enforced lockdowns and social distancing measures associated with COVID-19 may have influenced older adults’ preferences towards their homes and neighborhoods as well as social spaces.
Teck Hong Tan, Izian Idris
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Endpoints in T0-Quasimetric Spaces: Part II

Abstract and Applied Analysis, 2013
We continue our work on endpoints and startpoints in T0-quasimetric spaces. In particular we specialize some of our earlier results to the case of two-valued T0-quasimetrics, that is, essentially, to partial orders.
Collins Amburo Agyingi, Paulus Haihambo, Hans-Peter A. Künzi   +2 more
doaj   +1 more source

The Meaningful Lived Space of the Acute Stroke Unit: Creating Maps to Evoke the Experience of Stroke Survivors and Health Care Practitioners

International Journal of Qualitative Methods, 2020
Despite advocates for aesthetic forms of presentation in qualitative enquiry, for going beyond thin description, to share evocative forms of representation that resonate with that (Todres, 2008; Todres & Galvin, 2008), qualitative research in the health ...
Kitty Maria Suddick, Vinette Cross, Pirjo Vuoskoski, Kathleen T. Galvin, Graham Stew   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source