Results 61 to 70 of about 1,074,720 (325)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Distributed top-k aggregation queries at large [PDF]

, 2009
Top-k query processing is a fundamental building block for efficient ranking in a large number of applications. Efficiency is a central issue, especially for distributed settings, when the data is spread across different nodes in a network.
Neumann, T., Weikum, G., Bender, M., Peter Triantafillou, Sebastian Michel, Weikum, Gerhard, Triantafillou, P., Gerhard Weikum, Ralf Schenkel, Michel, Sebastian, Matthias Bender, Michel, S., Neumann, Thomas, Thomas Neumann, Schenkel, Ralf, Triantafillou, Peter, Schenkel, R., Bender, Matthias   +17 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comparative research on the formation of backbone media of wireless self-organizing network by DLA-GF algorithm and ant colony algorithm

Alexandria Engineering Journal, 2022
A mobile ad hoc network is a complicated distributed system organized by mobile terminals or wireless nodes through wireless connections. The mobile ad hoc network is suitable for those who lack basic communication equipment or do not have technical ...
Sihao Li, Tian Gao, Zhipeng Ye, Yaxing Wang   +3 more
doaj   +1 more source

On Valency-Based Molecular Topological Descriptors of Subdivision Vertex-Edge Join of Three Graphs [PDF]

Symmetry, 2020
In the studies of quantitative structure–activity relationships (QSARs) and quantitative structure–property relationships (QSPRs), graph invariants are used to estimate the biological activities and properties of chemical compounds. In these studies, degree-based topological indices have a significant place among the other descriptors because of the ...
Juan L. G. Guirao, Muhammad Imran, Muhammad Kamran Siddiqui, Shehnaz Akhter   +3 more
openaire   +1 more source

Asynchronous Distributed Execution Of Fixpoint-Based Computational Fields [PDF]

Logical Methods in Computer Science, 2017
Coordination is essential for dynamic distributed systems whose components exhibit interactive and autonomous behaviors. Spatially distributed, locally interacting, propagating computational fields are particularly appealing for allowing components to ...
Alberto Lluch Lafuente, Michele Loreti, Ugo Montanari   +2 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

On Distance-Based Topological Descriptors of Subdivision Vertex-Edge Join of Three Graphs [PDF]

IEEE Access, 2019
The analysis of networks and graphs through topological descriptors carries out a useful role to derive their underlying topologies. This process has been widely used in biomedicine, cheminformatics, and bioinformatics, where assessments based on graph invariants have been made available for effectively communicating with the various challenging ...
Hong Yang, Muhammad Imran 0006, Shehnaz Akhter, Zahid Iqbal, Muhammad Kamran Siddiqui   +4 more
openaire   +2 more sources

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

Advanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo, Shuo Qu, Shiming Gao, Xu Song   +3 more
wiley   +1 more source