Results 41 to 50 of about 3,027,351 (260)

Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles [PDF]

Journal of Extracellular Vesicles, 2016
Extracellular vesicles (EVs) in synovial fluid (SF) are gaining increased recognition as important factors in joint homeostasis, joint regeneration, and as biomarkers of joint disease.
Janneke Boere, Chris H. A. van de Lest, Sten F. W. M. Libregts, Ger J. A. Arkesteijn, Willie J. C. Geerts, Esther N. M. Nolte-'t Hoen, Jos Malda, P. René van Weeren, Marca H. M. Wauben   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Reduced Production of Pro-Inflammatory and Pro-Catabolic Factors by Human Serum Metabolites Derived from a Patented Saffron Extract Intake

Pharmaceutics
Safe and anti-inflammatory plant-based natural products present an increasing focus in the treatment of chronic inflammatory diseases such as osteoarthritis or inflammatory bowel diseases.
Line Pourtau, Fabien Wauquier, Line Boutin-Wittrant, David Gaudout, Benjamin Moras, Adeline Vignault, Carole Vaysse, Tristan Richard, Arnaud Courtois, Stéphanie Krisa, Véronique Roux, Nicolas Macian, Gisèle Pickering, Yohann Wittrant   +13 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Thin GB14 coatings on implants using HVSFS

Frontiers in Materials
Enhancing osseointegration, the process by which medical implants securely bond to bone, is crucial for improving patient outcomes in orthopedics and dental surgery.
Maria Carolina Lanzino, Long-Quan R. V. Le, Janka Wilbig, Wolfgang Rheinheimer, Michael Seidenstuecker, Jens Günster, Andreas Killinger   +6 more
doaj   +1 more source

HUMERORADIAL STABILIZATION WITH SCREWS ANDBRAIDEDPOLYESTER IN DOG WITH TRAUMATIC ELBOW LUXATION

UNINGÁ Review, 2020
The objective was to describe the case of a dog with traumatic elbow luxation that obtained good results after orthopedic correction with screws and braided polyesterin the formofan"8".
Leonardo Martins Leal, Carla Nazaré Magalhães, Gabriela Maria Benedetti Vasques, Diécila Milena Terezan, Thalissa Fernanda Ciboldi, Danielli Aparecida Lavelli   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel method to assess intraarticular screw penetration into the joint space

, 2020
Objectives: This study aims to propose a novel method to detect articular penetration of screws by relying on their electrical conductivity properties and control the validity of this method.
KÜÇÜKDURMAZ, FATİH
core   +1 more source

The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection [PDF]

, 2018
Objectives Periprosthetic joint infection following joint arthroplasty surgery is one of the most feared complications. The key to successful revision surgery for periprosthetic joint infections, regardless of treatment strategy, is a thorough deep ...
Simpson, AHRW, Gwynne, PJ, Gallagher, MP, Tsang, STJ   +3 more
core   +1 more source