Results 51 to 60 of about 6,682,328 (315)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis

Frontiers in Cell and Developmental Biology, 2020
A joint connects two or more bones together to form a functional unit that allows different types of bending and movement. Little is known about how the opposing ends of the connected bones are developed. Here, applying various lineage tracing strategies
Yi Zhang, Yi Zhang, Karl Annusver, Kazunori Sunadome, Polina Kameneva, Steven Edwards, Guanghua Lei, Maria Kasper, Andrei S. Chagin, Andrei S. Chagin, Igor Adameyko, Igor Adameyko, Meng Xie   +12 more
doaj   +1 more source

Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles [PDF]

Journal of Extracellular Vesicles, 2016
Extracellular vesicles (EVs) in synovial fluid (SF) are gaining increased recognition as important factors in joint homeostasis, joint regeneration, and as biomarkers of joint disease.
Janneke Boere, Chris H. A. van de Lest, Sten F. W. M. Libregts, Ger J. A. Arkesteijn, Willie J. C. Geerts, Esther N. M. Nolte-'t Hoen, Jos Malda, P. René van Weeren, Marca H. M. Wauben   +8 more
doaj   +1 more source

The development and evaluation of exercises for meaningful responses in reading in grade two [PDF]

, 1956
Research chapter for this study will be found in Ash, Dorothea: "Development and evaluation of silent reading exercises in grade one" Thesis (M.A.)--Boston ...
Bothwell, Joyce, Brown, Helen S., joint author, Campanaro, Dora M., joint author, Francis, Lena, joint author, Malm, Elsie L., joint author, Mortimer, Edith, joint author   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Reduced Production of Pro-Inflammatory and Pro-Catabolic Factors by Human Serum Metabolites Derived from a Patented Saffron Extract Intake

Pharmaceutics
Safe and anti-inflammatory plant-based natural products present an increasing focus in the treatment of chronic inflammatory diseases such as osteoarthritis or inflammatory bowel diseases.
Line Pourtau, Fabien Wauquier, Line Boutin-Wittrant, David Gaudout, Benjamin Moras, Adeline Vignault, Carole Vaysse, Tristan Richard, Arnaud Courtois, Stéphanie Krisa, Véronique Roux, Nicolas Macian, Gisèle Pickering, Yohann Wittrant   +13 more
doaj   +1 more source

Meaningful vocabulary practice in third grade reading, [PDF]

, 1956
Thesis (M.A.)--Boston ...
Barry, Helen, Simon, Anita,joint author, Wade, Alta M.,joint author., Wright, Lorraine,joint author   +3 more
core   +1 more source

Joint action goals reduce visuomotor interference effects from a partner’s incongruent actions [PDF]

, 2019
Joint actions often require agents to track others’ actions while planning and executing physically incongruent actions of their own. Previous research has indicated that this can lead to visuomotor interference effects when it occurs outside of joint ...
Butterfill, Stephen Andrew, Clarke, Sam, Francová, Anna, McEllin, Luke, Michael, John, Székely, Marcell   +5 more
core   +4 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Robust estimation of clinch joint characteristics based on data-driven methods [PDF]

, 2022
Christoph Zirngibl, Benjamin Schleich, Sandro Wartzack   +2 more
openalex   +1 more source