Results 71 to 80 of about 6,682,328 (315)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Extracellular Vesicles in Joint Disease and Therapy

open access: yesFrontiers in Immunology, 2018
The use of extracellular vesicles (EVs) as a potential therapy is currently explored for different disease areas. When it comes to the treatment of joint diseases this approach is still in its infancy.
Janneke Boere   +8 more
doaj   +1 more source

The use of joint attention in the naturalistic setting in children with Autism Spectrum Disorder [PDF]

open access: yes, 2015
This study investigates the deficits in the quantity and quality of joint attention in children with Autism Spectrum Disorder (ASD). To obtain a holistic measure of joint attention, the following four aspects were considered: a) the quantity of ...
Agius, Joseph, Dalli, Cheryl
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

La couleur et la brique : les exemples du Sud-Ouest de la France et de Saint-Germain-en-Laye

open access: yesBulletin du Centre de Recherche du Château de Versailles, 2002
Brick is man-made, which gives it a special status quite different to that of stone. It can be highly resistant and also extremely sophisticated. But usually, because of poorly controlled firing, it is quite irregular or even very rustic.
Bernard Voinchet
doaj   +1 more source

Data preservation, the new science and the practitioner librarian [PDF]

open access: yes, 2007
This paper outlines the information management principles of the so-called 'new science', and attempts to put these in the context of traditional library and information science principles.
Joint, Nicholas
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Functional Enabling and Physiotherapeutic Treatment of Sportsmen after Injuring Collateral Ligaments of Knee Joint [PDF]

open access: yesSport Mont, 2007
Ligamental compound of knee joint represents in mechanical terms, the most complex joint ligamental concatenation. According to seriousness and occurrence of damage, injuries of collateral ligaments can be divided into three degrees.
Vukosav Joksimović, Vukosav Joksimović
doaj  

Leprosy-Related Chronic Arthritis with an Abundance of Mycobacterium Leprae in the Synovial Fluid: A Rare Case

open access: yesInternational Medical Case Reports Journal, 2021
Hendra Gunawan, Yuli Wulansari, Pati Aji Achdiat, Reti Hindritiani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran – Hasan Sadikin General Hospital, Bandung, West Java, 40161, IndonesiaCorrespondence: Hendra ...
Gunawan H   +3 more
doaj  

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