Results 71 to 80 of about 8,450,023 (405)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Experimental Investigation on Joint Effects in Rock Cutting with a Conical Pick Under Unrelieved Cutting Conditions

Applied Sciences
In this study, a series of unrelieved cutting tests was conducted to analyze the effect of joints on rock cutting using a conical pick. The tests were performed on jointed rock mass specimens with joint spacings (Js) of 30, 60, and 90 mm and at cutting ...
Han-Eol Kim, Min-Seong Kim, Wan-Kyu Yoo, Chang-Yong Kim, Ji-Seok Yun   +4 more
doaj   +1 more source

Fracture Failure Numerical Simulation of Lug Joint Structure

Hangkong gongcheng jinzhan, 2019
Fracture of metallic materials is a difficult problem in engineering calculation. At present, researches on the ductile fracture of metal components are mostly based on the fracture samples of 10 kinds of classical plastic materials to analyze the ...
Lin Changliang, Hu Wengang, Liu Na
doaj   +1 more source

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis

Biomedicines, 2021
Genetic evidence suggests that three members of the VAV family (VAV1, VAV2 and VAV3) of signal transduction proteins could play important roles in rheumatoid arthritis.
Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero, Xosé R. Bustelo   +5 more
doaj   +1 more source

Oral versus Intravenous Antibiotics for Bone and Joint Infection

New England Journal of Medicine, 2019
BACKGROUND The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS
Ho‐Kwong Li, I. Rombach, R. Zambellas, S. Walker, M. McNally, B. Atkins, Benjamin A Lipsky, H. Hughes, D. Bose, Michelle Kümin, C. Scarborough, P. Matthews, A. Brent, J. Lomas, R. Gundle, M. Rogers, Adrian Taylor, B. Angus, I. Byren, A. Berendt, S. Warren, F. Fitzgerald, D. Mack, S. Hopkins, J. Folb, H. Reynolds, E. Moore, J. Marshall, N. Jenkins, C. E. Moran, A. Woodhouse, S. Stafford, A. Seaton, C. Vallance, C. Hemsley, K. Bisnauthsing, J. Sandoe, I. Aggarwal, S. Ellis, Deborah J. Bunn, R. Sutherland, G. Barlow, C. Cooper, C. Geue, N. McMeekin, A. Briggs, P. Sendi, E. Khatamzas, T. Wangrangsimakul, N. Wong, L. Barrett, A. Alvand, Fraser Old, J. Bostock, J. Paul, G. Cooke, G. Thwaites, P. Bejon, M. Scarborough   +58 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Mechanical and Tribological Performance of HDPE Matrix Reinforced by Hybrid Gr/TiO2 NPs for Hip Joint Replacement [PDF]

, 2023
Ahmed Nabhan, Galal Sherif, Ragab Abouzeid, Mohamed Taha   +3 more
openalex   +1 more source

Some comprehension problems in kindergarten, [PDF]

, 1956
Thesis (M.A.)--Boston ...
Baron, Rose Perlmuter, Levine, Nora,joint author, Loughlin, Claire Ann,joint author, Porter, Joan Louise,joint author   +3 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A Lipoma Arborescens Probably Causing Significant Osteoarthritis of the Elbow in a Young Man

Diagnostics
Lipoma arborescens (LA) is a rare, non-neoplastic, intra-articular, mass-like lesion with villous lipomatous proliferation that replaces and distends the synovium, particularly in the knee joint.
Won-Jong Bahk, Seungyup Shin, Junho Jang, Kyung Jin Seo, Yongju Kim, Hyunjung Kim   +5 more
doaj   +1 more source