Results 51 to 60 of about 92,495 (319)

Number of Doses of Systemic Antibiotic Prophylaxis May Be Reduced in Cemented Primary Knee Arthroplasty Irrespective of Use of Antibiotic in the Cement: A Multiregistry-Based Meta-Analysis

JBJS Open Access
Background:. The use of systemic antibiotic prophylaxis (SAP) and antibiotic-loaded bone cement (ALBC) is the accepted practice to reduce the risk of periprosthetic joint infection (PJI) in primary total knee arthroplasty (pTKA). However, practice varies
Tesfaye H. Leta, PhD, Richard N. Chang, MPH, Anne Marie Fenstad, MSc, Stein Atle Lie, PhD, Stein Håkon L. Lygre, PhD, Martin Lindberg-Larsen, PhD, Alma B. Pedersen, PhD, Olav Lutro, MD, Jinny Willis, PhD, Chris Frampton, PhD, Michael Wyatt, MD, Serban Dragosloveanu, MD, Andreea E. Vorovenci, MSc, Dan Dragomirescu, MSc, Håvard Dale, PhD, Geir Hallan, PhD, Jan-Erik Gjertsen, PhD, Heather A. Prentice, PhD, Ove Furnes, PhD, Art Sedrakyan, PhD, Elizabeth W. Paxton, PhD   +20 more
doaj   +1 more source

Patient-reported outcome measures in arthroplasty registries: Report of the Patient-Reported Outcome Measures Working Group of the International Society of Arthroplasty RegistriesPart I. Overview and rationale for patient-reported outcome measures

Acta Orthopaedica, 2016
The International Society of Arthroplasty Registries (ISAR) Steering Committee established the Patient-Reported Outcome Measures (PROMs) Working Group to convene, evaluate, and advise on best practices in the selection, administration, and interpretation
Ola Rolfson, Kate Eresian Chenok, Eric Bohm, Anne Lübbeke, Geke Denissen, Jennifer Dunn, Stephen Lyman, Patricia Franklin, Michael Dunbar, Søren Overgaard, Göran Garellick, Jill Dawson, the Patient-Reported Outcome Measures Working Group of the International Society of Arthroplasty Registries   +12 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Precision in Medial pivot total knee arthroplasty: A retrospective study on mechanical axis alignment and functional outcomes with CT-guided patient-specific instrumentation

SICOT-J
Background: Total Knee Arthroplasty (TKA) is the standard treatment for end-stage osteoarthritis, with optimal outcomes dependent on precise mechanical alignment and accurate implant positioning.
Mat Salleh Fadhil, Nizam Ikram
doaj   +1 more source

EOS ® orthopaedic imaging system to study patellofemoral kinematics : Assessment of uncertainty [PDF]

, 2010
The author extends his thanks to Dr. A. Asselineau, Pr David Mitton, Mr. Sébastien Laporte and Mr. Benjamin Aubert for their assistance.Background:Accurate knowledge of knee joint kinematics, especially patellofemoral joint kinematics, is essential for ...
F. Gabrielli, GABRIELLI, François, BONNET, Xavier, Azmy, C., Gabrielli, F., SKALLI, Wafa, Guérard, S., Skalli, W., GUÉRARD, Sandra, X. Bonnet, AZMI, Charaf, C. Azmy, W. Skalli, Bonnet, X., S. Guérard   +14 more
core   +1 more source

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Antibiotic-Loaded Bone Cement and Risk of Infection After Knee Arthroplasty in High-Risk Patients

JBJS Open Access
Background:. The use of antibiotic-loaded bone cement (ALBC) in primary total knee arthroplasty (TKA) is debated. Some argue that ALBC might only be justified in high-risk patients. This study assessed the effectiveness of ALBC vs. plain bone cement (PBC)
Tesfaye H. Leta, PhD, Richard N. Chang, MPH, Stein Atle Lie, PhD, Anne Marie Fenstad, MSc, Stein Håkon L. Lygre, PhD, Martin Lindberg-Larsen, PhD, Alma B. Pedersen, PhD, Annette W-Dahl, PhD, Ola Rolfson, PhD, Oskar Johansson, MSc, Liza N. van Steenbergen, PhD, Rob GHH Nelissen, PhD, Dylan Harries, PhD, Carl Holder, MBiostat, Peter Lewis, PhD, Richard de Steiger, PhD, Olav Lutro, MD, Keijo Mäkelä, PhD, Mikko S. Venäläinen, PhD, Jinny Willis, PhD, Chris Frampton, PhD, Michael Wyatt, PhD, Alexander Grimberg, MD, Arnd Steinbrück, PhD, Yinan Wu, MSc, Håvard Dale, PhD, Christian Brand, PhD, Bernhard Christen, MD, Joanne Shapiro, BSc, J. Mark Wilkinson, PhD, Morgan Edwards, PhD, Geir Hallan, PhD, Jan-Erik Gjertsen, PhD, Ove Furnes, PhD, Art Sedrakyan, PhD, Heather A. Prentice, PhD, Elizabeth W. Paxton, PhD   +36 more
doaj   +1 more source

The role of pain and function in determining patient satisfaction after total knee replacement - Data from the National Joint Registry for England and Wales

, 2007
A postal questionnaire was sent to 10 000 patients more than one year after their total knee replacement (TKR). They were assessed using the Oxford knee score and were asked whether they were satisfied, unsure or unsatisfied with their TKR.
Gregg, PJ, Baker, P.N., van der Meulen, J.H., Gregg, P.J., National Joint Registry for England and Wales, Lewsey, J, Lewsey, J., Baker, PN, van der Meulen, JH   +8 more
core   +1 more source