Results 81 to 90 of about 2,142,514 (292)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
When to Make the Sensory Social: Registering in Face-to-Face Openings [PDF]
, 2020 This article analyzes naturally occurring video-recorded openings during which participants make the sensory social through the action of registering—calling joint attention to a selected, publicly perceiv- able referent so others shift their sensory ...
Pillet-Shore, Danielle M
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Influence of Co-action on a Simple Attention Task: A Shift Back to the Status Quo
Frontiers in Psychology, 2018 There is a growing consensus among researchers that a complete description of human attention and action should include information about how these processes are informed by social context.
Jill A. Dosso +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
An Implexic Genealogical Analysis of the Absurd
HistoriesAccording to some, humanity’s search to answer the question “What is the meaning of life?” fuels the creative fires that forge all of civilization’s great religious, spiritual, and philosophical texts. But how seriously should we take the question?
Brian Lightbody
doaj +1 more source
Frontiers in Robotics and AI, 2016 Behavior associated with joint attention is among the most important human functionalities for communicating with others. Previous studies indicate that even a robot can learn these behavioral patterns as social skills through interaction with a modeled ...
Hamed eMahzoon +4 more
doaj +1 more source
The Efficacy of Joint Attention Interventions on Play Skills in Children with Autism Spectrum Disorder: A Systematic Review [PDF]
, 2018 Purpose:The aim of this study is to determine if joint attention interventions have an effect on general play skills in individuals with Autism Spectrum Disorder (ASD) aged birth to five years.
Esselstyn, Flinn +2 more
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source