Results 101 to 110 of about 1,667,185 (297)

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Maps and charts prepared by the Slum Clearance Committee of New York, 1933-34 : together with maps and charts of the Land Utilization Committee of the New York Building Congress as noted on the individual drawings included herein.

, 1934
Maps and charts prepared by the Slum Clearance Committee of New York, 1933-34.

core  

The 1976 annual report of the Great Lakes water quality [PDF]

, 1977
The International Joint Commission is pleased to transmit its Fifth Annual Report on Great Lakes Water Quality in accordance with the Great Lakes Water Quality Agreement of 1972. In this report the Commission has not attempted to provide a summary of the
International Joint Commission, United States and Canada
core   +1 more source

Coupled Dynamics and Nonlinear Behavior of 5-DoF Heavy-Load Mechanical Press with Multi-Type Clearance Joints Considering Lubricated and Dry Contact Conditions

Lubricants
Joint clearances inevitably deteriorate kinematic accuracy and operational stability of heavy-load mechanical presses. Most existing studies focus on single-type clearances or uniform contact states, failing to reveal the coupled dynamic behavior of ...
Xuze Wu, Qingyun Ye, Guo Li, Chunyuan Shi, Wen Liu, Hang Wang, Yu Chen   +6 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Shear joint capability versus bolt clearance [PDF]

, 1992
The results of a conservative analysis approach into the determination of shear joint strength capability for typical space-flight hardware as a function of the bolt-hole clearance specified in the design are presented. These joints are comprised of high-
Lee, H. M.
core  

Accuracy Analysis of a Multi-Closed-Loop Truss Antenna with Clearance

Aerospace
Surface accuracy is one of the most crucial indicators for evaluating the performance of a large deployable antenna. It depends on the accuracy of the truss structure of the truss antenna.
Di Wu, Jiang Zhao, Xiaofei Ma, Jinbao Chen, Chuanzhi Chen   +4 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Modeling and Analysis of the Flap Actuation System Considering the Nonlinear Factors of EMA, Joint Clearance and Flexibility

Aerospace
The performance of the flap actuation system directly affects the control effect and the flight quality of an aircraft. The electromechanical actuator (EMA) and the linkage mechanism are important components of the system.
Qi Wan, Chunyu Song, Yong Zhou, Ruiting Tong, Shangjun Ma, Geng Liu   +5 more
doaj   +1 more source