Results 61 to 70 of about 1,667,185 (297)

5-DOF Dynamic Model of Vehicle Shimmy System with Clearance at Universal Joint in Steering Handling Mechanism

Shock and Vibration, 2013
5-DOF dynamic model of vehicle shimmy system with clearance in universal joint of steering handling mechanism is presented. The sub model of cross shaft universal joint with clearance is built based on Hertz' theory, and two-state model is applied to ...
Jianwei Lu, Yi Xu, Chen Hu, Alexander F. Vakakis, Lawrence A. Bergman   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

POLYCENTRIC EXOPROSTHETIC KNEE JOINTS – EXTENT OF SHORTENING DURING SWING PHASE

Canadian Prosthetics & Orthotics Journal, 2020
BACKGROUND: An often assumed advantage of polycentric knee joints compared to monocentric ones is the improved ground clearance during swing phase due to the geometric shortening of the lower leg segment (LLS).
Thomas Maximilian Köhler, Malte Bellmann, Siegmar Blumentritt   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Posture and Dynamics Analysis of Hydraulic Support with Joint Clearance under Impact Load

Machines, 2023
A hydraulic support is one of the key pieces of equipment in a fully mechanized coal-mining face. The shaft is seriously worn due to repeated support shifting in coal-mining operations, and the hydraulic support bears a large amount of impact load in the
Qingliang Zeng, Penghui Xu, Zhaosheng Meng, Chen Ma, Xiaowan Lei   +4 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Effect of joint clearance on fatigue strength of brazed joint.

QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY, 1989
The effects of joint clearance on fatigue crack initiation life and crack growth rate of brazed joint were investigated.Tes tspecimens used were butt joint of carbon stcel and stainless steel brazed with pure copper with/without an artificial defect in joint.It was inferred from the fatigue test results that fatigue life of joint depend not on crack ...
openaire   +2 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The value of statistical life and cost-benefit evaluations of landmine clearance in Cambodia [PDF]

, 2008
Development agencies spend approximately US$400 million per year on landmine clearance. Yet many cost-benefit evaluations suggest that landmine clearance is socially wasteful because costs appear to far outweigh social benefits.
Helmers, Kent, Cameron, Michael Patrick, Tressler, John, Lim, Steven, Vaddanak, Kien, Gibson, John   +5 more
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