Results 71 to 80 of about 1,390,207 (300)
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
The value of statistical life and cost-benefit evaluations of landmine clearance in Cambodia [PDF]
, 2008 Development agencies spend approximately US$400 million per year on landmine clearance. Yet many cost-benefit evaluations suggest that landmine clearance is socially wasteful because costs appear to far outweigh social benefits.
Helmers, Kent +5 more
core
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Dynamics Simulation and Experiment of the Slider-crank Mechanism with Dry Friction Clearance Joint
Jixie chuandong, 2017 Based on dynamics simulation software,the dynamics analysis of the slider-crank mechanism with clearance joint is carried out and the effect of joint with different clearance size under dry contact and non-friction conditions on dynamic response of ...
Han Yuncheng, Xu Lixin, Huang Xiaoqiu
doaj
International Journal of Mechanical System Dynamics, 2021 Due to assembly, wear and manufacturing errors and clearance in the joints are inevitable. When the clearance is introduced into a mechanical system, the impact force in the clearance joint will cause undesirable vibration of the system.
Zhengfeng Bai, Fusong Xu, Jijun Zhao
doaj +1 more source
Identifying joint clearance via robot manipulation
, 2017 Inaccuracy in robot manipulation is a result of various uncertainties. Most methods reduce operation errors by calibrating robot parameters, with little attention on understanding the uncertainty sources in the process.
Kuan-Lin Li +2 more
core +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Jixie chuandong, 2001 This paper takes account of the boundary condition of elements of a joint with clearance when contact occur, by using the nonlinear spring damper formulation to model the resulting reaction force between the elements of clearance joint.
王国庆, 刘宏昭
doaj
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source