Joint Modeling of An Outcome Variable and Integrated Omic Datasets Using GLM-PO2PLS [PDF]
In many studies of human diseases, multiple omic datasets are measured. Typically, these omic datasets are studied one by one with the disease, thus the relationship between omics are overlooked. Modeling the joint part of multiple omics and its association to the outcome disease will provide insights into the complex molecular base of the disease.
arxiv
Bone and Joint Diseases: Prevention and Control [PDF]
Arthritis is Australia's major cause of disability and chronic pain. In Australian women, osteoarthritis is the third leading cause of years lost due to disability. Osteoporosis affects nearly two million Australians.
Brooks, Peter M.+2 more
core +1 more source
A Spatio-Temporal Multivariate Shared Component Model with an Application in Iran Cancer Data [PDF]
Among the proposals for joint disease mapping, the shared component model has become more popular. Another recent advance to strengthen inference of disease data has been the extension of purely spatial models to include time and space-time interaction. Such analyses have additional benefits over purely spatial models.
arxiv +1 more source
Joint Haplotype Assembly and Genotype Calling via Sequential Monte Carlo Algorithm [PDF]
Genetic variations predispose individuals to hereditary diseases, play important role in the development of complex diseases, and impact drug metabolism. The full information about the DNA variations in the genome of an individual is given by haplotypes,
Ahn, Soyeon, Vikalo, Haris
core +3 more sources
Ultrasonography of the painful hip in childhood [PDF]
There are many diseases in childhood that affect the hip joint. Some diseases are systemic in origin and initially may present themselves as hip disorders, such as rheumatoid arthritis.
Robben, S.G.F. (Simon)
core +2 more sources
Teenagers’ understandings of and attitudes towards vaccines and vaccine-preventable diseases: a qualitative study [PDF]
<p>Background: To examine immunisation information needs of teenagers we explored understandings of vaccination and vaccine-preventable diseases, attitudes towards immunisation and experiences of immunisation.
Barbour+48 more
core +1 more source
A multinomial truncated D-vine copula mixed model for the joint meta-analysis of multiple diagnostic tests [PDF]
There is an extensive literature on methods for meta-analysis of diagnostic studies, but it mainly focuses on a single test. However, the better understanding of a particular disease has led to the development of multiple tests. A multinomial generalized linear mixed model (GLMM) is recently proposed for the joint meta-analysis of studies comparing ...
arxiv
a comparative study with ultrasonography [PDF]
Background Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wrist and finger joints.
Backhaus, Marina+11 more
core +1 more source
Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies [PDF]
Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis.
Christopher I. Amos+11 more
core +1 more source