Results 61 to 70 of about 4,125,277 (310)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

Frontiers in Physiology, 2018
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host,
Kelsey H. Collins, Kelsey H. Collins, Walter Herzog, Walter Herzog, Graham Z. MacDonald, Raylene A. Reimer, Raylene A. Reimer, Jaqueline L. Rios, Jaqueline L. Rios, Jaqueline L. Rios, Ian C. Smith, Ronald F. Zernicke, Ronald F. Zernicke, Ronald F. Zernicke, David A. Hart, David A. Hart, David A. Hart, David A. Hart   +17 more
doaj   +1 more source

Three-dimensional geometrical modelling of the femoral intramedullary cavity using ring cyclide model

, 2020
Objectives: This study aims to investigate if geometrical modelling in addition to three-dimensional (3D) modelling will standardize models and allow performing mathematical calculations easily for the compatibility of femoral implant curvature. Patients
Akkoyunlu, Nuran A. Sabir, Akman, Alp, Demirkan, Ahmet Fahir   +2 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Genetic causal relationship between physical activity and osteoarthritis: a two-sample Mendelian randomization study

Archives of Medical Science
Introduction Appropriate levels of physical activity (PA) can help prevent osteoarthritis (OA) and alleviate its symptoms. However, excessive or prolonged PA has been identified as a potential risk factor for OA.
Mingyi Yang, Hui Yu, Yani Su, Pengfei Wen, Jiale Xie, Xianjie Wan, Ke Xu, Zhi Yang, Lin Liu, Peng Xu   +9 more
doaj   +1 more source

Radiation synovectomy therapy combined with surgical synovectomy in chronic nonspecific synovitis of the knee joint

, 2013
Objectives: This study aims to investigate the effectiveness of the radiation synovectomy (RS) procedure combined with the surgical synovectomy in the treatment of chronic nonspecific synovitis, which are resistant to medical treatment.
Korkmaz, Murat, Ozturk, Hayati, Oztemur, Zekeriya, Tezeren, Gunduz, Bulut, Okay   +4 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Deep Learning-Augmented Zero Echo Time MRI Increases Diagnostic Confidence for Osseous Assessment in Hand and Foot MRI Protocols

Diagnostics
Background/Objectives: This study assesses the outcomes of integrating deep learning-augmented zero echo time (ZTE DL) MRI sequences into standard MRI protocols for assessment of the hands and feet.
Carina Obermüller, Karolina Pawlus, Maelene Lohezic, Jose de Arcos Rodriguez, Roman Guggenberger, Malwina Kaniewska   +5 more
doaj   +1 more source

Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus

Journal of Immunology Research, 2023
Diffuse alveolar haemorrhage (DAH) is a rapidly developing condition owing to a lack of effective treatment and resulting in a high mortality rate in systemic lupus erythematosus (SLE).
Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang   +10 more
doaj   +1 more source

Hyaluronan in joint disease [PDF]

Journal of Internal Medicine, 1997
Engström‐Laurent A (University of Umeå, Umeå, Sweden). Hyaluronan in joint disease (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 57–60.Hyaluronan is a major component of synovial fluid. It is synthesized in the joint and partly degraded in joint capsule and partly carried by lymph to lymph nodes and the general circulation.
openaire   +2 more sources