Results 81 to 90 of about 674,929 (309)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Neglected bilateral congenital dislocation of the patella

, 2017
Congenital dislocation of the patella is a disorder that presents with dysfunction in extensor mechanism. Although congenital dislocation of the patella mostly occurs in children with genetic disorders, it may also occur in totally healthy children ...
Tokgoz, Mehmet Ali and Cavusoglu, Ali Turgay and Ayanoglu, Tacettin and Elma, Tarik and Vural, Abdurrahman
core   +1 more source

Simultaneous versus staged surgeries for the treatment of bilateral developmental hip dysplasia in walking age: A comparison of complications and outcomes

, 2021
Objectives: This study aims to compare the radiological outcomes and rate of complication between single-stage and staged operation for the treatment of bilateral developmental dysplasia of the hip (DDH). Patients and methods: A total of 100 patients (13
TUNCER, Kutsi, YILAR, Sinan, AYDIN, Ali, KÖSE, Mehmet, Zencirli, Kemal, Topal, Murat   +5 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Salter innominate osteotomy for the treatment of developmental dysplasia of the hip: 37 years of follow-up

, 2015
In this article, we report the radiological and clinical status at postoperative 37th year of a 39-year-old male patient who was treated with bilateral Salter innominate osteotomy due to bilateral developmental dysplasia of the hip when he was two years ...
Atik, O. Sahap and Daldal, Ismail
core   +1 more source

A case of a ganglion cyst originating from the hip joint and surgical outcome

Acta Orthopaedica et Traumatologica Turcica, 2021
Ganglion cysts are the most common soft tissue tumors of the hand, wrist, and foot. However, those originating from the hip joint are not so frequent. This case report presents a 36-year-old woman who complained of pain in the right groin. A diagnosis of
Senol Akman, Bulent Gur, Tevfik Sulun, Bulent Aksoy   +3 more
doaj  

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Italian Guidelines for the Diagnosis and Infectious Disease Management of Osteomyelitis and Prosthetic Joint Infections in Adults

, 2009
Bone and joint infections are recognized as difficult-to-treat infections that result in significant morbidity and mortality among patients and increased healthcare costs.
VENDITTI, Mario, S. Leone, S. Borre, F. Mazzotta, S. Esposito, M. Bassetti, E. Meani, O. F. Infectious Tropical Diseases Bone Joint Infections Committee For The Italian Society, F. Leoncini   +8 more
core   +1 more source

CHILD WITH JOINT PAIN AT THE PRIMARY CARE LEVEL

Slovenska pediatrija
Joint pain is a common reason for a child’s visit to primary care. While most cases are benign and self-limiting, joint pain may be the first manifestation of serious underlying conditions such as trauma, septic arthritis, juvenile idiopathic arthritis ...
David Horvat, Denis Baš
doaj   +1 more source