Results 51 to 60 of about 1,329,973 (305)

Astragalus membranaceus Extract Attenuates Inflammatory Cytokines and Matrix-Degrading Enzymes in Human Chondrocytes: A Novel Nutraceutical Strategy for Joint Health

Current Issues in Molecular Biology
The dried root extract of Astragalus membranaceus, also known as Astragali radix, is widely used in traditional Chinese medicine for its multiple health benefits and well-established safety profile.
Alessia Mariano, Rosario Russo, Anna Scotto d’Abusco, Fabiana Superti   +3 more
doaj   +1 more source

Joint diseases in animal paleopathology: Veterinary approach

Macedonian Veterinary Review, 2015
Animal paleopathology is not a very well known scientific discipline within veterinary science, but it has great importance for historical and archaeological investigations.
Oliver Stevanović, , Maciej Janeczek, , Aleksander Chrószcz, Nemanja Marković   +3 more
doaj   +1 more source

Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections [PDF]

, 2019
Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat in both veterinary and human clinical practice.
Conlon, Brian P., Gilbertie, Jessica M., Hickok, Noreen J., Jacob, Megan E., Parvizi, Javad, Schaer, Thomas P., Schnabel, Lauren V., Shapiro, Irving   +7 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

Frontiers in Physiology, 2018
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host,
Kelsey H. Collins, Kelsey H. Collins, Walter Herzog, Walter Herzog, Graham Z. MacDonald, Raylene A. Reimer, Raylene A. Reimer, Jaqueline L. Rios, Jaqueline L. Rios, Jaqueline L. Rios, Ian C. Smith, Ronald F. Zernicke, Ronald F. Zernicke, Ronald F. Zernicke, David A. Hart, David A. Hart, David A. Hart, David A. Hart   +17 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Retrospective Evaluation of Synovial Chondromatosis with Histopathological and Clinical Features

Forbes Tıp Dergisi
Objective: Synovial chondromatosis (SC) is a rare, benign condition characterized by the formation of nodular cartilage within the synovium of joints, bursae, or tendon sheaths.
Özden ÖZ, Murat SEZAK, Başak DOĞANAVŞARGİL, İpek TAMSEL, Hüseyin KAYA, Elcil KAYA BİÇER, Emin BÜYÜKTALANCI, Gülçin BAŞDEMİR   +7 more
doaj   +1 more source

Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus

Journal of Immunology Research, 2023
Diffuse alveolar haemorrhage (DAH) is a rapidly developing condition owing to a lack of effective treatment and resulting in a high mortality rate in systemic lupus erythematosus (SLE).
Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang   +10 more
doaj   +1 more source

Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study [PDF]

, 2003
AIM: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.
Balogh, Zsuzsanna, Dávid, Gyula, Kuronya, Pál, Lakatos, László, Lakatos, Péter László, Pandur, Tünde, Tollas, Árpád   +6 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source