Results 41 to 50 of about 6,396,845 (310)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Physiological incongruity of the humero-ulnar joint [PDF]

open access: yes, 1993
Investigations into the distribution of subchondral bone density in the human elbow have suggested that the geometry of the trochlear notch deviates from a perfect fit with the trochlea, and that the load is transmitted ventrally and dorsally rather than
Löhe, F.   +5 more
core   +1 more source

Advanced Iterative Procedures for Solving the Implicit Colebrook Equation for Fluid Flow Friction

open access: yesAdvances in Civil Engineering, 2018
The empirical Colebrook equation from 1939 is still accepted as an informal standard way to calculate the friction factor of turbulent flows (4000 
Pavel Praks, Dejan Brkić
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Integrating Entropy and Copula Theories for Hydrologic Modeling and Analysis

open access: yesEntropy, 2015
Entropy is a measure of uncertainty and has been commonly used for various applications, including probability inferences in hydrology. Copula has been widely used for constructing joint distributions to model the dependence structure of multivariate ...
Zengchao Hao, Vijay P. Singh
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Infrared Image Classification and Detection Algorithm for Power Equipment Based on Improved YOLOv10

open access: yesIEEE Access
Real-time target detection has important applications in industry. Identifying the type of power equipment in massive infrared image data for heat fault diagnosis has emerged as a crucial issue that needs to be addressed in this field.
Xiu Ji   +3 more
doaj   +1 more source

Modelling Risk Dependencies in Insurance Using Survival Clayton Copula [PDF]

open access: yesStatistika: Statistics and Economy Journal
Our aim in this paper is to show the use of survival Clayton copula as a suitable tool for modelling risk dependencies in insurance. Apurpose-built simulation of an adequate upper tail dependence can be an important part of the aggregation of risks in an
Vladimír Mucha   +2 more
doaj   +1 more source

Joint Distributions for Interacting Fluid Queues

open access: yesQueueing Systems, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dirk P. Kroese, Werner R. W. Scheinhardt
openaire   +6 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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