Results 41 to 50 of about 12,297,484 (296)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Effectiveness of Thai Massage and Joint Mobilization

International Journal of Therapeutic Massage & Bodywork: Research, Education, & Practice, 2017
Background: Non-specific low back pain (LBP) is a common health problem resulting from many risk factors and human behaviors. Some of thesemay interact synergistically and have been implicated in the cause of low back pain. Massage both traditional Thai massage and joint mobilization as a common practice has been shown to be effective for some subgroup
Chantip, Juntakarn, Thavat, Prasartritha, Prapoj, Petrakard   +2 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Effect of Loading on the Contact Stress of UHMWPE Material for Artificial Hip Joint Bearing [PDF]

, 2012
An artificial hip joint consists of several main components. The components are femoral stem, femoral head, acetabular liner and acetabular shell. As its function as a bearing, an acetabular liner is designed to reduce friction and receive the high ...
J, Jamari, Iwan , Budiwan Anwar, Rifky , Ismail, Eko , Saputra   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Projecting potential population exposure to the invasive malaria vector Anopheles stephensi

Environmental Research Letters
Malaria remains a major global public health threat, and the recent invasion and rapid spread of Anopheles stephensi across Africa pose new challenges for disease control. To assess future risks, we estimated the distribution of An.
Yelin Sun, Weihang Liu, Yuanyuan Jing, Tian Liu, Meng Shang, Yujuan Yue, Yuhong Guo, Qiyong Liu   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A New Method to Describe the Combined Effect of Draught and Radiant Thermal Asymmetry on Human Work Performance

Slovak Journal of Civil Engineering, 2020
Human resources are the most important elements of economic units; thus, the efficiency of human work is of crucial importance. Work efficiency can be achieved only in an environment offering optimal thermal comfort.
András-Tövissi Balázs, Kajtár László   +1 more
doaj   +1 more source