Results 91 to 100 of about 812,084 (287)

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Combining transcriptomics and biochemical analysis to understand the accumulation changes of polysaccharides in different harvest periods of Gastrodia elata

Industrial Crops and Products
Gastrodia elata polysaccharides (GEP), recognized for their diverse biological activities, are significant bioactive components of the orchid Gastrodia elata Blume.
Yunfei Hu, Na Yang, Jinsong He, Ming Zhao, Xiaofeng Ren, Qingyan Tang   +5 more
doaj   +1 more source

A Bayesian approach to the study of white dwarf binaries in LISA data: The application of a reversible jump Markov chain Monte Carlo method

, 2009
The Laser Interferometer Space Antenna (LISA) defines new demands on data analysis efforts in its all-sky gravitational wave survey, recording simultaneously thousands of galactic compact object binary foreground sources and tens to hundreds of ...
Stroeer, Alexander, Veitch, John
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Quality analysis and characteristic difference identification of organic tea and conventional planting tea based on ICP, HPLC and machine algorithm

Food Chemistry: X
With the continuous expansion of the organic tea industry, distinguishing the authenticity of organic tea is crucial to maintain the market's stability. Thus, organic and conventional planting teas (green teas) of Dajianshan were selected as the objects ...
De Zhou, Yunfei Hu, Xi He, Lijuan Du, Lian Bao, Ming Zhao, Jinliang Shao, Qingyan Tang   +7 more
doaj   +1 more source

Joint Entity Extraction and Assertion Detection for Clinical Text

, 2019
Negative medical findings are prevalent in clinical reports, yet discriminating them from positive findings remains a challenging task for information extraction.
Bhatia, Parminder, Celikkaya, Busra, Khalilia, Mohammed   +2 more
core   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Clinical study on the effects of elongated third molar extraction on the temporomandibular joint

Kouqiang hemian waike zazhi
[Objective:] To investigate the effects of elongated third molars on the temporomandibular joint function, masticatory muscle electromyographic activity, and joint space.
Gaozhaer Buhareali, JIANG Haoyu, SONG Zhiqiang, Habeeb Hussam, ZHANG Lu, GONG Zhongcheng   +5 more
doaj   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Optimization of saponin extraction from the leaves of Panax notoginseng and Panax quinquefolium and evaluation of their antioxidant, antihypertensive, hypoglycemic and anti-inflammatory activities

Food Chemistry: X
Panax notoginseng and Panax quinquefolium are important economic plants that utilize dried roots for medicinal and food dual purposes; there is still insufficient research of their stems and leaves, which also contain triterpenoid saponins.
Zheng-Wei Liang, Yan-Hui Guan, Zheng Lv, Sheng-Chao Yang, Guang-Hui Zhang, Yin-He Zhao, Ming Zhao, Jun-Wen Chen   +7 more
doaj   +1 more source