Results 51 to 60 of about 812,084 (287)

Maqian (Zanthoxylum myriacanthum var. pubescens) bark extract alleviates DSS-induced colitis via dual TLR4/NF-κB inhibition and intestinal barrier restoration

Industrial Crops and Products
Ulcerative colitis (UC) prevalence is increasing in Asia, with limited treatment options. Increasing treatment needs for UC warrant exploration of ethnopharmacological resources.
Qing-Fei Fan, Xiao-Lin Liu, Sheng-Chao Yang, Wei-Wei Jiang, Jun-Wen Chen, Juan Luo, Ming Zhao   +6 more
doaj   +1 more source

B→Dlν form factors at nonzero recoil and extraction of |Vcb| [PDF]

, 2015
We present a lattice QCD calculation of the B→Dlν semileptonic decay form factors f+(q2) and f0(q2) for the entire physical q2 range. Nonrelativistic QCD bottom quarks and highly improved staggered quark charm and light quarks are employed together with ...
Bouchard, Chris M., Lepage, G. Peter, Monahan, Chris, Na, Heechang, Shigemitsu, Junko   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Brain Extraction from Normal and Pathological Images: A Joint PCA/Image-Reconstruction Approach

, 2018
Brain extraction from images is a common pre-processing step. Many approaches exist, but they are frequently only designed to perform brain extraction from images without strong pathologies.
Asturias, Alexander, Aylward, Stephen, Bakas, Spyridon, Han, Xu, Kwitt, Roland, Menze, Bjoern, Niethammer, Marc, Van Horn, John, Vespa, Paul   +8 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Make It Directly: Event Extraction Based on Tree-LSTM and Bi-GRU

IEEE Access, 2020
Event extraction is an important research direction in the field of natural language processing (NLP) applications including information retrieval (IR).
Wentao Yu, Mianzhu Yi, Xiaohui Huang, Xiaoyu Yi, Qingjun Yuan   +4 more
doaj   +1 more source

Joint Entity and Relation Extraction Network with Enhanced Explicit and Implicit Semantic Information

Applied Sciences, 2022
The main purpose of the joint entity and relation extraction is to extract entities from unstructured texts and extract the relation between labeled entities at the same time. At present, most existing joint entity and relation extraction networks ignore
Huiyan Wu, Jun Huang
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

CJE-PCHF: Chinese Joint Entity and Relation Extraction Model Based on Progressive Contrastive Learning and Heterogeneous Feature Fusion

Applied Sciences
The joint extraction of entities and relations is a critical task in information extraction, and its performance directly affects the performance of downstream tasks.
Meng He, Yunli Bai, Dongye Wei
doaj   +1 more source

Joint Acoustic Echo Cancellation and Blind Source Extraction Based on Independent Vector Extraction

2022 International Workshop on Acoustic Signal Enhancement (IWAENC), 2022
We describe a joint acoustic echo cancellation (AEC) and blind source extraction (BSE) approach for multi-microphone acoustic frontends. The proposed algorithm blindly estimates AEC and beamforming filters by maximizing the statistical independence of a non-Gaussian source of interest and a stationary Gaussian background modeling interfering signals ...
Haubner, Thomas, Koldovský, Zbyněk, Kellermann, Walter   +2 more
openaire   +2 more sources