Results 31 to 40 of about 136,839 (256)

The reverse coracoacromial ligament transfer for “horizontal” acromioclavicular joint instability

JSES Reviews, Reports, and Techniques, 2021
Background: Acromioclavicular (AC) horizontal instability is a problem affecting not only young athletic patients after a trauma to the AC joint but also older patients who have undergone distal clavicle resection.
Jessica L. Mowbray, MBCHB, Gabriela Moreno, MD, Christiaan G.M. Albers, MD, Peter Poon, FRACS   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Reproducibility of T All-Inside Arthroscopic ATFL Repair With Internal Brace Augmentation: Multicenter Midterm Outcomes in Chronic Lateral Ankle Instability

Journal of the Foot & Ankle
Introduction: Chronic lateral ankle instability (CLAI) may require surgery after failed nonoperative care. We evaluated functional outcomes of a true all-inside arthroscopic anterior talofibular ligament (ATFL) repair augmented with suture tape internal
Gustavo Araújo Nunes, Caio Augusto de Souza Nery, Gabriel Ferraz Ferreira, Roberto Zambelli de Almeida Pinto, Daniel Soares Baumfeld, Paula Costa Machado   +5 more
doaj   +1 more source

Instability of the distal radioulnar joint

Deutsches Ärzteblatt international
Instability of the distal radioulnar joint (DRUJ) is an often unrecognized complication of distal radius fractures and softtissue injuries that can impair function. Its incidence and prevalence in Germany in 2023 were 23.55 and 30.55 per 100 000 inhabitants, respectively.This narrative review is based on publications retrieved by a selective search in ...
Harbrecht, Andreas, Unglaub, Frank, Langer, Martin Franz, Müller, Lars Peter, Hug, Urs, Spies, Christian Karl   +5 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Comparison of radiological features of high tibial osteotomy and tibial condylar valgus osteotomy

BMC Musculoskeletal Disorders, 2019
Background The purpose of this study was to compare radiological features between high tibial osteotomy (HTO) and tibial condylar valgus osteotomy (TCVO), in order to define the radiological indication criteria for TCVO.
Takashi Higuchi, Hironobu Koseki, Akihiko Yonekura, Ko Chiba, Yusuke Nakazoe, Shinya Sunagawa, Chieko Noguchi, Makoto Osaki   +7 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Leg and Joint Stiffness of the Supporting Leg during Side-Foot Kicking in Soccer Players with Chronic Ankle Instability

Sports, 2023
Soccer players with chronic ankle instability (CAI) may stabilize their supporting leg by the proximal joint to compensate for the ankle instability during kicking motion.
Akihiro Tamura, Keita Shimura, Yuri Inoue   +2 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source