Results 41 to 50 of about 136,839 (256)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Lateral subtalar joint capsuloligamentous instability: A review and proposed repair technique

Foot & Ankle Surgery: Techniques, Reports & Cases
Lateral subtalar joint (STJ) instability is an underrecognized contributor to persistent lateral hindfoot symptoms, especially among patients who continue to feel unstable after anatomically successful anterior talofibular ligament (ATFL) and ...
Marque Allen, DPM, FACFAS Fellowship Director, Seth Ashraf, DPM, AACFAS Current Fellow, Jacob Riddle, DPM 2nd Year Resident, Ian Vandergulik, DPM Past Fellow, Christopher Bibbo, DO, DPM FACS, FAAOS, FACFAS, Orthopedic Surgeon   +4 more
doaj   +1 more source

[Subtalar joint instability].

Acta orthopaedica et traumatologica turcica, 2003
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KAYAOGLU, E., BİNNET, Mehmet
openaire   +2 more sources

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Functional Outcome of Lateral Extraarticular Tenodesis (LET) Procedure in Addition to Anterior Cruciate Ligament Reconstruction: A Metaanalysis

Revista Brasileira de Ortopedia, 2022
Objectives The aim of the present study is to systematically review and analyze the functional outcome of lateral extraarticular tenodesis (LET) procedure in addition to anterior cruciate ligament reconstruction (ACLR) in studies with a high level of ...
I Gusti Ngurah Wien Aryana, I Wayan Subawa, I Wayan Suryanto Dusak, Cokorda Gde Oka Dharmayuda, Hans Kristian Nugraha, Maria Florencia Deslivia   +5 more
doaj   +2 more sources

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Minimal Important Change and Minimal Clinically Important Difference in Pain and Function With Exercise in Hip Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to estimate the minimal important change (MIC) and minimal clinically important difference (MCID) for pain and physical function in individuals with hip osteoarthritis (OA) following a physiotherapist‐guided exercise intervention.
Yareni Guerrero, Fiona Dobson, Venkatesha Venkatesha, Kim Allison, Gabrielle Knox, Libby Spiers, Travis Haber, David J Hunter, Michelle Hall   +8 more
wiley   +1 more source

Using an Electronic Goniometer to Assess the Influence of Single-Application Kinesiology Taping on Unstable Shoulder Proprioception and Function

Sensors
Background: Glenohumeral joint instability is associated with a proprioception deficit. Joint position sense can be improved through targeted exercises and kinesiology taping (KT). While previous studies have examined the effects of KT on proprioception,
Ewa Bręborowicz, Izabela Olczak, Przemysław Lubiatowski, Piotr Ogrodowicz, Marta Ślęzak, Maciej Bręborowicz, Leszek Romanowski   +6 more
doaj   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Chronic Instability and Pain of the Sternoclavicular Joint: Treatment With Semitendinosus Allograft to Restore Joint Stability

Arthroscopy Techniques, 2019
Chronic instability of the sternoclavicular (SC) joint is a challenging clinical problem, particularly in a patient population for which nonoperative forms of treatment prove ineffective.
Liam A. Peebles, B.A., Zachary S. Aman, B.A., Fletcher R. Preuss, B.S., Brian T. Samuelsen, M.D., M.B.A., Tyler J. Zajac, M.S., A.T.C., O.T.C., Ravi B. Patel, M.D., CAPTM.D., M.C., U.S.N.R. Matthew T. Provencher, M.D.   +6 more
doaj   +1 more source