Results 201 to 210 of about 1,649,528 (252)

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Lower-limb biomechanical alterations across movement tasks in individuals with chronic ankle instability: An umbrella review of systematic reviews and meta-analyses. [PDF]

Mechanobiol Med
Xuan B, Sun D, Song Y, Li F, Zhou Z, Wang Z, Zhu J, Chen K, Zhao R, Wang D, Chen D, Janicijevic D, Jemni M, Gu Y.   +13 more
europepmc   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Evaluation of Chronic Lateral Ankle Instability With an Ankle Sprain Simulator: A Controlled Study in Physically Active Subjects. [PDF]

J Foot Ankle Res
Lalevée M, Melone MA, l'Hermette M, Beldame J, de Cesar Netto C, Schmidt E, Wilken J.   +6 more
europepmc   +1 more source

Efficient Cholesteric Liquid Crystal Waveguide Polarizing Splitters for High‐Sensitivity Chip‐Scale Atomic Magnetometry

Advanced Science, EarlyView.
An integrated polarimetry architecture based on a cholesteric liquid crystal waveguide polarization splitter overcomes the volumetric bottleneck in chip‐scale atomic magnetometers. By leveraging Bragg‐selective reflection and total‐internal‐reflection‐induced helicity inversion, this ultrathin device enables efficient circular polarization splitting ...
Zhibo Cui, Chuang Wang, Xiangyang Zhou, Gaopu Hou, Jinsheng Hu, Mao Ye, Xu Xiao, Zhen Chai, Yishi Weng, Yuning Zhang   +9 more
wiley   +1 more source

The impact of physical-mental mixed fatigue on landing biomechanics inter-joint coordination and injury risk in elite American football players. [PDF]

Front Psychol
Wang Z, Cui H, Lu J, Meng L, Xuan B, Zhu Y, Wang P, An J, Zhang Q, Wang X.   +9 more
europepmc   +1 more source

Monolayer MoS2 With Ultrahigh Piezoelectricity: From ALD Dose Control to Device Performance

Advanced Science, EarlyView.
This study demonstrates that controlling precursor dosages in atomic layer deposition (ALD) serves to regulate ultrathin oxide quality, which in turn determines sulfurization behavior and MoS2 monolayer continuity. The resulting continuous, low‐defect monolayers enable improved piezoelectric performance and support a flexible slippage sensor, linking ...
Yun Li, Ming Rui Joel Tan, Subhasis Das, Yafei Du, Wenjie Lai, Jiamin Amanda Ong, Yongli He, Yiming Zou, Anatoli Kurkin, Peiwen Huang, Jiajun Liu, Xingyu Chen, Alfred Iing Yoong Tok, Soo Jay Phee, Lioz Etgar, Shlomo Magdassi, Pooi See Lee   +16 more
wiley   +1 more source

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

Advanced Science, EarlyView.
A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng, Yi Zhu, Xinrui Li, Sunxian Dai, Xiangyuan Ma, Hongwei Lu, Zhongling Wang, Benqing Zhou   +7 more
wiley   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Tolerance Inversion for Lens Support Loads Based on Feature-Enhanced Active-Learning Gaussian Process Regression. [PDF]

Micromachines (Basel)
Liu J, Li S, Kang X, Xian S, Zhou J, Liu J.   +5 more
europepmc   +1 more source