Results 51 to 60 of about 5,185,714 (288)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Is the position of the femur tibia joint under feedback control in the walking stick insect?: II. Electrophysiological recordings [PDF]

, 1981
Cruse H, Pflüger H-J. Is the position of the femur tibia joint under feedback control in the walking stick insect?: II. Electrophysiological recordings. The journal of experimental biology.
Pflüger, H.-J., Cruse, Holk
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Differences in body fat mass muscular endurance coordination and proprioception in woman with and without knee pain: a crosssectional study

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: The aim of this study was to compare body fat mass, muscular endurance, multi-joint coordination and proprioception between sedentary adult woman with and without knee pain.\r\nMethods: This cross-sectional study included 149 women.
Derya Ozer Kaya, Irem Duzgun, Gul Baltaci   +2 more
doaj   +1 more source

Comparing position sense and isokinetic strength of the muscles of elbow joint between aikidokas and non-athlete people

BMC Sports Science, Medicine and Rehabilitation, 2023
Background Aikido is a martial art comprises of locking techniques and falls. During the locking techniques, the elbow joint is forced into extended position. Moreover, the elbow hits the ground during the falling techniques. These might compromise joint
Rezvan Mirsalari, Amin Kordi Yoosefinejad, Farzaneh Yazdani, Farzaneh Haghighat, Ali Asghar Amiripanah, Saeid Parandavarfard   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Effects of local treatment with and without sensorimotor and balance exercise in individuals with neck pain: protocol for a randomized controlled trial

BMC Musculoskeletal Disorders, 2018
Background Impaired cervical joint position sense and balance are associated with neck pain. Specific therapeutic exercise and manual therapy are effective for improving neck pain and functional ability but their effects on joint position sense and ...
Munlika Sremakaew, Gwendolen Jull, Julia Treleaven, Marco Barbero, Deborah Falla, Sureeporn Uthaikhup   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Menstrual Cycle Does Not Influence Joint Position Sense, Joint Kinesthesia, and Dynamic Balance [PDF]

, 2010
Context:. The prevalence of anterior cruciate ligament (ACL) injuries in female athletes appears to be highest during the late luteal and early follicular phases of the menstrual cycle.
Harriell, Kysha
core   +2 more sources