Results 51 to 60 of about 1,205,082 (300)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Effect of Six Weeks of Neuromuscular Training on Joint Position Sense and Lower Extremity Function in Male Athletes with Functional Ankle Instability [PDF]

Sport Sciences and Health Research, 2017
Lateral ankle sprain is the most common ligament injury in athletes and functional instability is one of the disabling consequences of the ankle sprain.
Hadi Samadi, Reza Rajabi, Mohammad Karimizadeh Ardakani   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Differences in body fat mass muscular endurance coordination and proprioception in woman with and without knee pain: a crosssectional study

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: The aim of this study was to compare body fat mass, muscular endurance, multi-joint coordination and proprioception between sedentary adult woman with and without knee pain.\r\nMethods: This cross-sectional study included 149 women.
Derya Ozer Kaya, Irem Duzgun, Gul Baltaci   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Effects of local treatment with and without sensorimotor and balance exercise in individuals with neck pain: protocol for a randomized controlled trial

BMC Musculoskeletal Disorders, 2018
Background Impaired cervical joint position sense and balance are associated with neck pain. Specific therapeutic exercise and manual therapy are effective for improving neck pain and functional ability but their effects on joint position sense and ...
Munlika Sremakaew, Gwendolen Jull, Julia Treleaven, Marco Barbero, Deborah Falla, Sureeporn Uthaikhup   +5 more
doaj   +1 more source

Comparing position sense and isokinetic strength of the muscles of elbow joint between aikidokas and non-athlete people

BMC Sports Science, Medicine and Rehabilitation, 2023
Background Aikido is a martial art comprises of locking techniques and falls. During the locking techniques, the elbow joint is forced into extended position. Moreover, the elbow hits the ground during the falling techniques. These might compromise joint
Rezvan Mirsalari, Amin Kordi Yoosefinejad, Farzaneh Yazdani, Farzaneh Haghighat, Ali Asghar Amiripanah, Saeid Parandavarfard   +5 more
doaj   +1 more source

ARE JOINT POSITION SENSE, TWO-POINT DISCRIMINATION, FINE MOTOR CONTROL, GRIP STRENGTH, LIGHT TOUCH SENSATION, PAIN, AND FUNCTIONALITY AFFECTED BILATERALLY IN UNILATERAL CARPAL TUNNEL SYNDROME?

İstanbul Tıp Fakültesi Dergisi, 2022
Objective: This study aimed to evaluate joint position sense, two-point discrimination, fine motor control, grip strength, light touch sensation, pain, and functionality in patients with unilateral carpal tunnel syndrome and to determine whether these ...
Gülfem Ezgi Özaltın, Havva Adlı, Burcu Talu   +2 more
doaj   +1 more source

Errors in Shoulder Joint Position Sense Mainly Come from the Glenohumeral Joint [PDF]

Journal of Applied Biomechanics, 2017
While synchronous movement of the glenohumeral and scapulothoracic joints has been emphasized in previous kinematics studies, most investigations of shoulder joint position sense have treated the shoulder complex as a single joint. The purposes of this study were to investigate the joint position sense errors of the humerothoracic, glenohumeral, and ...
Yin-Liang, Lin, Andrew, Karduna
openaire   +2 more sources