Results 61 to 70 of about 82,544 (253)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The effectiveness of proprioceptive training for improving motor function: a systematic review

Frontiers in Human Neuroscience, 2015
Objective: Numerous reports advocate that training of the proprioceptive sense is a viable behavioral therapy for improving impaired motor function. However, there is little agreement of what constitutes proprioceptive training and how effective it is ...
Joshua E Aman, Joshua E Aman, Naveen eElangovan, I-Ling eYeh, Juergen eKonczak, Juergen eKonczak   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Aging Alters the Sense of Force but Not the Sense of Position in the Wrist and Ankle Joints

Gerontology
Introduction: The impact of aging on proprioceptive senses remains an open question. As the senses of position and force may rely on different neural substrates, we investigated the effect of aging on both senses to provide original and more comprehensive data on age-related changes in proprioception.
Henry, Mélanie, Baudry, Stéphane
openaire   +3 more sources

The Effect of Cryotherapy on the Normal Ankle Joint Position Sense

Asian Journal of Sports Medicine, 2011
To determine whether a fifteen-minute water immersion treatment affects the normal ankle joint position sense (JPS) at the middle range of dorsiflexion and plantar flexion actively and passively.Thirty healthy female volunteers aged between 18 and 30 years were treated by a 15-minute cryotherapy (6 ± 1°C).
Roya, Khanmohammadi, Marjan, Someh, Farahnaze, Ghafarinejad   +2 more
openaire   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The Short-Term Effects of Kinesio Tape on Joint Position Sense, Sense of Force and Postural Control in Patients with Functional Ankle Instability

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018
BACKGROUND AND OBJECTIVE: Functional ankle instability is a common musculoskeletal injury. Patients with impaired proprioception and permanent impairment in postural stability. The aim of this study is to investigate the short-term effect of kinesio tape
H Momeni-lari, M Ghasemi, Kh Khademi-kalantari, A Akbarzadeh-baghban   +3 more
doaj  

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

The Comparison of the Effect of Deep and Superficial Heat on Healthy Ankle Joint Position Sense

Journal of Rehabilitation Sciences and Research, 2014
Background: Heat therapy is one of the natural treatments that can affect the information transferred by the proprioceptive receptors. Heat has an effect on the conduction velocity of peripheral nerves, but the exact effect of two kinds of deep and ...
Farahnaz Ghaffarinejad, Farzaneh Moslemi Haghighi, Soraya Pirouzi, Shohreh Taghizadeh, Tahereh Motiallah, Nasrin Salehi   +5 more
doaj  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source