Results 61 to 70 of about 1,205,082 (300)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The neural basis of central proprioceptive processing in older versus younger adults: An important sensory role for right putamen [PDF]

, 2012
Our sense of body position and movement independent of vision (i.e., proprioception) relies on muscle spindle feedback and is vital for performing motor acts.
Abe, Adamovich, Andersson, Beaulieu, Bhagat, Boska, Chan, Christensen, Corbetta, Cordo, Coxon, Crutcher, Daprati, DeLong, Fjell, Folstein, Friston, Friston, Goble, Goble, Goble, Goble, Goble, Goble, Goble, Goble, Goble, Goble, Goble, Goble, Goodwin, Halligan, Hasan, Henry, Heuninckx, Heuninckx, Hurley, Jones, Kaasinen, Kavounoudias, Konczak, Kunzle, Kunzle, Lajoie, Le Bihan, LeBel, Leemans, Leemans, Lehericy, Lemon, Lidsky, Liu, Maschke, McChesney, Mima, Miwa, Montant, Naito, Naito, Naito, Oldfield, Pfefferbaum, Phillips, Roll, Roll, Romaiguere, Rothwell, Sainburg, Schoenbaum, Seidler, Snook, Swash, Swinnen, Talairach, Tanji, Vaillancourt, Van Hecke, Van Hecke, Van Impe, Wang, Ward, Ward, Weiller, Wong, Wu, Yoshikawa, Zhang, Zia, Zia   +88 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effect of sustained experimental muscle pain on joint position sense

PAIN Reports, 2019
. Introduction:. Joint position sense (JPS) is impaired in clinical musculoskeletal pain conditions, but when this impairment develops in the transition from initial to prolonged pain is not known. Objectives:.
Simon J. Summers, Siobhan M. Schabrun, Rogerio P. Hirata, Thomas Graven-Nielsen, Rocco Cavaleri, Lucy S. Chipchase   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Distinguishing Motor Weakness From Impaired Spatial Awareness: A Helping Hand! [PDF]

, 2017
Our patient, aged 73 years, had background peripheral neuropathy of unknown cause, stable for several years, which caused some difficulty in walking on uneven ground. He attended for a teaching session but now staggered in, a new development.
Bardhan, K., Raju, S., Swift, R.
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of positioning and bracing on passive position sense of shoulder joint [PDF]

British Journal of Sports Medicine, 2004
Objective:To examine the effects of positioning and sleeve type bracing on passive position sense of shoulder joints of healthy untrained subjects.Method:A cross over study was carried out on 26 subjects (13 male, 13 female) with a proprioception measurement device. The selected method of testing was passive reproduction of a target angle.
Guner, RS, Ulkar, B, Kunduracioglu, B, Cetin, C   +3 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Joint Attention, Union with God, and the Dark Night of the Soul [PDF]

, 2013
Eleonore Stump has argued that the fulfilment of union between God and human beings requires a mode of relatedness that can be compared to joint attention, a phenomenon studied in contemporary experimental psychology.
Bungum, Donald
core   +1 more source